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    EHBP1 EH domain binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 23301, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EHBP1provided by HGNC
    Official Full Name
    EH domain binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:29144
    See related
    Ensembl:ENSG00000115504 MIM:609922; AllianceGenome:HGNC:29144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPC12; NACSIN
    Summary
    This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 15.6), fat (RPKM 14.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EHBP1 in Genome Data Viewer
    Location:
    2p15
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (62673878..63046487)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (62680198..63053564)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (62901013..63273622)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:62804913-62806112 Neighboring gene ribosomal L24 domain containing 1 pseudogene 2 Neighboring gene phosphoserine aminotransferase 1 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:62874108-62874609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:62898481-62898982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15871 Neighboring gene Sharpr-MPRA regulatory region 1961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63062886-63063515 Neighboring gene VISTA enhancer hs690 Neighboring gene ribosomal protein S20 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15873 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63270899-63271878 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63271879-63272858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:63274968-63275716 Neighboring gene VISTA enhancer hs1066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63280773-63281719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:63283391-63283950 Neighboring gene EHBP1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 3143 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 pseudogene Neighboring gene orthodenticle homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population. Beikzadeh B, et al. BMC Med Genet, 2020 Apr 15. PMID 32295536, Free PMC Article
    2. The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Rai A, et al. Nat Commun, 2020 Aug 21. PMID 32826901, Free PMC Article
    3. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Li Z, et al. Sci Adv, 2016 Dec. PMID 28028537, Free PMC Article
    4. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. Guilherme A, et al. J Biol Chem, 2004 Mar 12. PMID 14676205
    5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Gudmundsson J, et al. Nat Genet, 2008 Mar. PMID 18264098, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
      Title: The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.
    2. The purpose of this study was to evaluate the association of rs16901979, rs4242382 and rs1447295 on 8q24 locus, rs2735839 (KLK3 gene) and rs721048 (EHBP1 gene) with prostate adenocarcinoma through multi-stage approach to identify the polymorphisms associated with prostate cancer and use them as screening factors
      Title: Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.
    3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.
    4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Meta-analysis of genome-wide and replication association studies on prostate cancer.
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Validation of genome-wide prostate cancer associations in men of African descent.
    7. EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton
      Title: EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Prostate cancer, hereditary, 12
    MedGen: C2678479 OMIM: 611868 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0903

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    EH domain-binding protein 1
    Names
    NPF calponin-like protein
    testis tissue sperm-binding protein Li 50e

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016758.2 RefSeqGene

      Range
      36863..377637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142614.2 → NP_001136086.1  EH domain-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001136086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK292545, AY531390, BC067215, DB072549
      Consensus CDS
      CCDS46299.1
      UniProtKB/TrEMBL
      A0A140VK17, A8K930
      Conserved Domains (3) summary
      pfam00307
      Location:412 → 508
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1035 → 1175
      DUF3585; Protein of unknown function (DUF3585)

    2. NM_001142615.3 → NP_001136087.1  EH domain-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001136087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two in-frame exons in the coding region, compared to variant 1. This variant encodes a shorter isoform (3) than isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC007098, AK292545, BC067215
      Consensus CDS
      CCDS46300.1
      UniProtKB/TrEMBL
      A8K930
      Related
      ENSP00000384143.3, ENST00000405015.7
      Conserved Domains (4) summary
      pfam00307
      Location:412 → 514
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1003 → 1139
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:239 → 348
      NPF; Rabosyn-5 repeating NPF sequence-motif

    3. NM_001142616.3 → NP_001136088.1  EH domain-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001136088.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons in the coding region, compared to variant 1. This variant encodes a shorter isoform (3) than isoform 1. Variants 3, 4 and 11 encode the same isoform (3).
      Source sequence(s)
      AC092567, BC067215, CA394214, HY174910
      Consensus CDS
      CCDS46300.1
      UniProtKB/TrEMBL
      A8K930
      Related
      ENSP00000403783.1, ENST00000431489.6
      Conserved Domains (4) summary
      pfam00307
      Location:412 → 514
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1003 → 1139
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:239 → 348
      NPF; Rabosyn-5 repeating NPF sequence-motif

    4. NM_001354212.1 → NP_001341141.1  EH domain-binding protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AC092567, AY331186, AY531390, BC067215, BP361773, DA403235
      Consensus CDS
      CCDS1872.1
      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1074 → 1210
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    5. NM_001354213.1 → NP_001341142.1  EH domain-binding protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AY331186, AY531390, BC067215, BP361773, DA403235, DB072549
      Consensus CDS
      CCDS1872.1
      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1074 → 1210
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    6. NM_001354214.1 → NP_001341143.1  EH domain-binding protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AY331186, AY531390, BC067215, BP361773, DA403235, DB072549
      Consensus CDS
      CCDS1872.1
      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1074 → 1210
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    7. NM_001354215.1 → NP_001341144.1  EH domain-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AY331186, AY531390, BC067215, BP361773, BQ215191, DA403235, DB072549
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (3) summary
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1076 → 1204
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:444 → 550
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    8. NM_001354216.2 → NP_001341145.1  EH domain-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AY331186, AY531390, BC067215, BP361773, BQ215191, DA312518, DA403235
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (3) summary
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1076 → 1204
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:444 → 550
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    9. NM_001354217.1 → NP_001341146.1  EH domain-binding protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AY531390, BC029477, BC067215, BP361773, DA403235, DA558402
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1038 → 1174
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    10. NM_001354218.1 → NP_001341147.1  EH domain-binding protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      BC067215, DB072549
      Consensus CDS
      CCDS46300.1
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:412 → 514
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1003 → 1139
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:239 → 348
      NPF; Rabosyn-5 repeating NPF sequence-motif

    11. NM_001354219.2 → NP_001341148.1  EH domain-binding protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC092567, BC067215, CA394214, DA555784, HY174910
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:412 → 514
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1002 → 1138
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:239 → 348
      NPF; Rabosyn-5 repeating NPF sequence-motif

    12. NM_001354220.1 → NP_001341149.1  EH domain-binding protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      BC067215, DA555784, DB072549
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:412 → 514
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1002 → 1138
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:239 → 348
      NPF; Rabosyn-5 repeating NPF sequence-motif

    13. NM_001354221.2 → NP_001341150.1  EH domain-binding protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC092567, AY331186, AY531390, BC067215, BP361773, CA394214, DA403235, HY174910
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 525
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:792 → 928
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    14. NM_001354222.2 → NP_001341151.1  EH domain-binding protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC092567, BC067215, CA394214, HY174910
      Conserved Domains (4) summary
      pfam00307
      Location:412 → 490
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:721 → 857
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:239 → 348
      NPF; Rabosyn-5 repeating NPF sequence-motif

    15. NM_015252.5 → NP_056067.2  EH domain-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056067.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 5, 6, and 7 encode the same isoform (1).
      Source sequence(s)
      AC092567, AY331186, AY531390, BC067215, BP361773, CA394214, DA403235, HY174910
      Consensus CDS
      CCDS1872.1
      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930
      Related
      ENSP00000263991.5, ENST00000263991.9
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1074 → 1210
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      62673878..63046487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443744.1 → XP_047299700.1  EH domain-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930

    2. XM_011532718.4 → XP_011531020.1  EH domain-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (2) summary
      pfam00307
      Location:327 → 423
      CH; Calponin homology (CH) domain
      pfam12130
      Location:950 → 1090
      DUF3585; Protein of unknown function (DUF3585)

    3. XM_047443745.1 → XP_047299701.1  EH domain-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930

    4. XM_047443748.1 → XP_047299704.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    5. XM_047443749.1 → XP_047299705.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930
      Related
      ENSP00000385524.1, ENST00000405289.5

    6. XM_017003650.2 → XP_016859139.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1038 → 1174
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    7. XM_047443751.1 → XP_047299707.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    8. XM_047443758.1 → XP_047299714.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A8K930

    9. XM_047443762.1 → XP_047299718.1  EH domain-binding protein 1 isoform X10

    10. XM_047443770.1 → XP_047299726.1  EH domain-binding protein 1 isoform X14

    11. XM_047443767.1 → XP_047299723.1  EH domain-binding protein 1 isoform X11

    12. XM_047443773.1 → XP_047299729.1  EH domain-binding protein 1 isoform X15

    13. XM_047443754.1 → XP_047299710.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K930

    14. XM_047443747.1 → XP_047299703.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    15. XM_047443756.1 → XP_047299712.1  EH domain-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K930

    16. XM_047443753.1 → XP_047299709.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    17. XM_047443763.1 → XP_047299719.1  EH domain-binding protein 1 isoform X10

    18. XM_011532715.4 → XP_011531017.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011531017.1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1074 → 1210
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    19. XM_047443757.1 → XP_047299713.1  EH domain-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K930

    20. XM_047443764.1 → XP_047299720.1  EH domain-binding protein 1 isoform X10

    21. XM_006711971.4 → XP_006712034.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1038 → 1174
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    22. XM_011532717.3 → XP_011531019.1  EH domain-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (3) summary
      pfam00307
      Location:447 → 543
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1033 → 1173
      DUF3585; Protein of unknown function (DUF3585)

    23. XM_047443768.1 → XP_047299724.1  EH domain-binding protein 1 isoform X12

    24. XM_047443760.1 → XP_047299716.1  EH domain-binding protein 1 isoform X9

    25. XM_047443769.1 → XP_047299725.1  EH domain-binding protein 1 isoform X13

    26. XM_005264227.2 → XP_005264284.1  EH domain-binding protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005264284.1

      UniProtKB/TrEMBL
      A0A140VK17, A8K930
      Conserved Domains (3) summary
      pfam00307
      Location:412 → 508
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1035 → 1175
      DUF3585; Protein of unknown function (DUF3585)

    27. XM_047443750.1 → XP_047299706.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    28. XM_047443761.1 → XP_047299717.1  EH domain-binding protein 1 isoform X10

    29. XM_047443766.1 → XP_047299722.1  EH domain-binding protein 1 isoform X11

    30. XM_047443772.1 → XP_047299728.1  EH domain-binding protein 1 isoform X15

    31. XM_005264226.4 → XP_005264283.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005264283.1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930
      Conserved Domains (4) summary
      pfam00307
      Location:447 → 549
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1074 → 1210
      DUF3585; Protein of unknown function (DUF3585)
      pfam16601
      Location:274 → 383
      NPF; Rabosyn-5 repeating NPF sequence-motif

    32. XM_047443746.1 → XP_047299702.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    33. XM_047443755.1 → XP_047299711.1  EH domain-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K930

    34. XM_047443752.1 → XP_047299708.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    35. XM_047443759.1 → XP_047299715.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A8K930

    36. XM_047443765.1 → XP_047299721.1  EH domain-binding protein 1 isoform X10

    37. XM_047443771.1 → XP_047299727.1  EH domain-binding protein 1 isoform X14

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      62680198..63053564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341085.1 → XP_054197060.1  EH domain-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930

    2. XM_054341105.1 → XP_054197080.1  EH domain-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A8K930

    3. XM_054341086.1 → XP_054197061.1  EH domain-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930

    4. XM_054341099.1 → XP_054197074.1  EH domain-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A8K930

    5. XM_054341106.1 → XP_054197081.1  EH domain-binding protein 1 isoform X9

    6. XM_054341115.1 → XP_054197090.1  EH domain-binding protein 1 isoform X13

    7. XM_054341090.1 → XP_054197065.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    8. XM_054341091.1 → XP_054197066.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    9. XM_054341094.1 → XP_054197069.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K930

    10. XM_054341093.1 → XP_054197068.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    11. XM_054341103.1 → XP_054197078.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A8K930

    12. XM_054341108.1 → XP_054197083.1  EH domain-binding protein 1 isoform X10

    13. XM_054341116.1 → XP_054197091.1  EH domain-binding protein 1 isoform X14

    14. XM_054341113.1 → XP_054197088.1  EH domain-binding protein 1 isoform X11

    15. XM_054341119.1 → XP_054197094.1  EH domain-binding protein 1 isoform X15

    16. XM_054341098.1 → XP_054197073.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K930

    17. XM_054341089.1 → XP_054197064.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    18. XM_054341101.1 → XP_054197076.1  EH domain-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K930

    19. XM_054341097.1 → XP_054197072.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    20. XM_054341109.1 → XP_054197084.1  EH domain-binding protein 1 isoform X10

    21. XM_054341084.1 → XP_054197059.1  EH domain-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930

    22. XM_054341102.1 → XP_054197077.1  EH domain-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K930

    23. XM_054341110.1 → XP_054197085.1  EH domain-binding protein 1 isoform X10

    24. XM_054341095.1 → XP_054197070.1  EH domain-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K930

    25. XM_054341114.1 → XP_054197089.1  EH domain-binding protein 1 isoform X12

    26. XM_054341087.1 → XP_054197062.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    27. XM_054341092.1 → XP_054197067.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    28. XM_054341107.1 → XP_054197082.1  EH domain-binding protein 1 isoform X10

    29. XM_054341112.1 → XP_054197087.1  EH domain-binding protein 1 isoform X11

    30. XM_054341118.1 → XP_054197093.1  EH domain-binding protein 1 isoform X15

    31. XM_054341083.1 → XP_054197058.1  EH domain-binding protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O94977, Q53TG7, Q53TV6, Q580X2, Q6NX72, Q6PIT3, Q6QNV2, Q8NDI1, Q9NWI9
      UniProtKB/TrEMBL
      A8K930

    32. XM_054341088.1 → XP_054197063.1  EH domain-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A140VK17, A8K930

    33. XM_054341100.1 → XP_054197075.1  EH domain-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K930

    34. XM_054341096.1 → XP_054197071.1  EH domain-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K930

    35. XM_054341104.1 → XP_054197079.1  EH domain-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A8K930

    36. XM_054341111.1 → XP_054197086.1  EH domain-binding protein 1 isoform X10

    37. XM_054341117.1 → XP_054197092.1  EH domain-binding protein 1 isoform X14

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NDI1.3 GenPept UniProtKB/Swiss-Prot:Q8NDI1

    Gene LinkOut

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