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    LINC01126 long intergenic non-protein coding RNA 1126 [ Homo sapiens (human) ]

    Gene ID: 100129726, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01126provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1126provided by HGNC
    Primary source
    HGNC:HGNC:49275
    See related
    Ensembl:ENSG00000279873 AllianceGenome:HGNC:49275
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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    Genomic context

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    See LINC01126 in Genome Data Viewer
    Location:
    2p21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (43227211..43228855)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (43232577..43234221)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (43454350..43455994)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43404972-43405498 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1717 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43407075-43407600 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:43411165-43412364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43412481-43413214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43413949-43414682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43414683-43415416 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:43421149-43422068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43437212-43437806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43441787-43442553 Neighboring gene VISTA enhancer hs1909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43453393-43454356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11423 Neighboring gene ZFP36 ring finger protein like 2 Neighboring gene Sharpr-MPRA regulatory region 2712 Neighboring gene THADA armadillo repeat containing Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43500316-43500816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43500817-43501317 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:43519973-43521172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43524271-43524772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15672 Neighboring gene RNA, U6 small nuclear 958, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15673 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:43653235-43654434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15677 Neighboring gene RNA, 7SL, cytoplasmic 531, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Androgen-repressed lncRNA LINC01126 drives castration-resistant prostate cancer by regulating the switch between O-GlcNAcylation and phosphorylation of androgen receptor. Cai Y, et al. Clin Transl Med, 2024 Jan. PMID 38214432, Free PMC Article
    2. Long non-coding RNA 01126 promotes periodontitis pathogenesis of human periodontal ligament cells via miR-518a-5p/HIF-1α/MAPK pathway. Zhou M, et al. Cell Prolif, 2021 Jan. PMID 33231338, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Androgen-repressed lncRNA LINC01126 drives castration-resistant prostate cancer by regulating the switch between O-GlcNAcylation and phosphorylation of androgen receptor.
      Title: Androgen-repressed lncRNA LINC01126 drives castration-resistant prostate cancer by regulating the switch between O-GlcNAcylation and phosphorylation of androgen receptor.
    2. Long non-coding RNA 01126 promotes periodontitis pathogenesis of human periodontal ligament cells via miR-518a-5p/HIF-1alpha/MAPK pathway.
      Title: Long non-coding RNA 01126 promotes periodontitis pathogenesis of human periodontal ligament cells via miR-518a-5p/HIF-1α/MAPK pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Clone Names

    • MGC40574

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027251.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AW297558, BC032412, CR738297
      Related
      ENST00000623515.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      43227211..43228855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      43232577..43234221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178529.2: Suppressed sequence

      Description
      NM_178529.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein
    Heading Accession and Version

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