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    ZNF345 zinc finger protein 345 [ Homo sapiens (human) ]

    Gene ID: 25850, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF345provided by HGNC
    Official Full Name
    zinc finger protein 345provided by HGNC
    Primary source
    HGNC:HGNC:16367
    See related
    Ensembl:ENSG00000251247 AllianceGenome:HGNC:16367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZF10
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.1), skin (RPKM 1.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF345 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36850365..36893218)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39526030..39568903)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37341267..37384120)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC728485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene zinc finger protein 790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14535 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37368334-37369533 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37382329-37383528 Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene zinc finger protein 568

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor. Moosmann P, et al. Biol Chem, 1997 Jul. PMID 9278146
    2. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
    3. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
    4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36827, FLJ51247, FLJ96023, MGC33794

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 345
    Names
    zinc finger protein HZF10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242472.2 → NP_001229401.1  zinc finger protein 345

      See identical proteins and their annotated locations for NP_001229401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AK315069, BC032863, DB289823
      Consensus CDS
      CCDS12497.1
      UniProtKB/Swiss-Prot
      Q14585
      Related
      ENSP00000431216.1, ENST00000420450.6
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001242474.2 → NP_001229403.1  zinc finger protein 345

      See identical proteins and their annotated locations for NP_001229403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AK315069, BC032863, BP195158, DB289823
      Consensus CDS
      CCDS12497.1
      UniProtKB/Swiss-Prot
      Q14585
      Related
      ENSP00000431289.2, ENST00000532141.6
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001242475.2 → NP_001229404.1  zinc finger protein 345

      See identical proteins and their annotated locations for NP_001229404.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AC008733, BC032863, DB028175, DB289823
      Consensus CDS
      CCDS12497.1
      UniProtKB/Swiss-Prot
      Q14585
      Related
      ENSP00000331120.5, ENST00000331800.9
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001242476.2 → NP_001229405.1  zinc finger protein 345

      See identical proteins and their annotated locations for NP_001229405.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AC008733, BC032863, DB028175, DB085650, DB289823
      Consensus CDS
      CCDS12497.1
      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_003419.5 → NP_003410.1  zinc finger protein 345

      See identical proteins and their annotated locations for NP_003410.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2 through 5 encode the same protein.
      Source sequence(s)
      BC032863, DB096099, DB289823
      Consensus CDS
      CCDS12497.1
      UniProtKB/Swiss-Prot
      Q14585
      Related
      ENSP00000465431.1, ENST00000589046.1
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_038362.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has alternate 5' and 3' sequences, compared to variant 1. The transcript does not have a supported open reading frame and therefore does not encode a protein.
      Source sequence(s)
      AC008733, DA625929

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36850365..36893218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438566.1 → XP_047294522.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585

    2. XM_017026568.2 → XP_016882057.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_017026573.2 → XP_016882062.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_017026569.3 → XP_016882058.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_011526704.4 → XP_011525006.1  zinc finger protein 345 isoform X1

      See identical proteins and their annotated locations for XP_011525006.1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_017026570.3 → XP_016882059.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_017026572.3 → XP_016882061.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_017026571.3 → XP_016882060.1  zinc finger protein 345 isoform X1

      UniProtKB/Swiss-Prot
      Q14585
      Conserved Domains (2) summary
      COG5048
      Location:88 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39526030..39568903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320479.1 → XP_054176454.1  zinc finger protein 345 isoform X1

    2. XM_054320477.1 → XP_054176452.1  zinc finger protein 345 isoform X1

    3. XM_054320482.1 → XP_054176457.1  zinc finger protein 345 isoform X1

    4. XM_054320476.1 → XP_054176451.1  zinc finger protein 345 isoform X1

    5. XM_054320474.1 → XP_054176449.1  zinc finger protein 345 isoform X1

    6. XM_054320483.1 → XP_054176458.1  zinc finger protein 345 isoform X1

    7. XM_054320480.1 → XP_054176455.1  zinc finger protein 345 isoform X1

    8. XM_054320478.1 → XP_054176453.1  zinc finger protein 345 isoform X1

    9. XM_054320481.1 → XP_054176456.1  zinc finger protein 345 isoform X1

    10. XM_054320475.1 → XP_054176450.1  zinc finger protein 345 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14585.1 GenPept UniProtKB/Swiss-Prot:Q14585

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