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    ZNF35 zinc finger protein 35 [ Homo sapiens (human) ]

    Gene ID: 7584, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF35provided by HGNC
    Official Full Name
    zinc finger protein 35provided by HGNC
    Primary source
    HGNC:HGNC:13099
    See related
    Ensembl:ENSG00000169981 MIM:194533; AllianceGenome:HGNC:13099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HF10; HF.10; Zfp105
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 5.6), urinary bladder (RPKM 2.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF35 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44646506..44660791)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44662214..44676499)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44690224..44702283)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene zinc finger protein 197 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. Donti E, et al. Hum Genet, 1990 Apr. PMID 2108922
    2. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. Lanfrancone L, et al. Genomics, 1992 Apr. PMID 1572646
    3. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. Pannuti A, et al. Nucleic Acids Res, 1988 May 25. PMID 3380682, Free PMC Article
    4. The ZNF35 human zinc finger gene encodes a sequence-specific DNA-binding protein. Pengue G, et al. FEBS Lett, 1993 Apr 26. PMID 8477855
    5. Expression of zinc finger protein 105 in the testis and its role in male fertility. Zhou H, et al. Mol Reprod Dev, 2010 Jun. PMID 20186958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 35
    Names
    zinc finger protein 35 (clone HF.10)
    zinc finger protein HF.10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003420.4 → NP_003411.3  zinc finger protein 35

      See identical proteins and their annotated locations for NP_003411.3

      Status: VALIDATED

      Source sequence(s)
      AC099669, BC013597, BC015892, BP237260
      Consensus CDS
      CCDS2718.2
      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
      Related
      ENSP00000379368.2, ENST00000396056.7
      Conserved Domains (4) summary
      COG5048
      Location:214 → 369
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336 → 356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:474 → 496
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:488 → 513
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44646506..44660791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448870.1 → XP_047304826.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    2. XM_047448869.1 → XP_047304825.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    3. XM_047448866.1 → XP_047304822.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    4. XM_047448867.1 → XP_047304823.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    5. XM_047448868.1 → XP_047304824.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      171860..186145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331561.1 → XP_054187536.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    2. XM_054331560.1 → XP_054187535.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    3. XM_054331558.1 → XP_054187533.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    4. XM_054331559.1 → XP_054187534.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    5. XM_054331557.1 → XP_054187532.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44662214..44676499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347767.1 → XP_054203742.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    2. XM_054347766.1 → XP_054203741.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    3. XM_054347764.1 → XP_054203739.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    4. XM_054347765.1 → XP_054203740.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01

    5. XM_054347763.1 → XP_054203738.1  zinc finger protein 35 isoform X1

      UniProtKB/Swiss-Prot
      B2RBU6, P13682, Q53Y54, Q96D01
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13682.4 GenPept UniProtKB/Swiss-Prot:P13682

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