RAB7B RAB7B, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB7Bprovided by HGNC
Official Full Name: RAB7B, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:30513
See related: Ensembl:ENSG00000276600 AllianceGenome:HGNC:30513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAB7
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in late endosome to Golgi transport; positive regulation of megakaryocyte differentiation; and regulation of gene expression. Located in cytoplasmic vesicle; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in skin (RPKM 15.7), gall bladder (RPKM 6.5) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (205976740..206003395, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (205240788..205267388, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34.
Title: Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34.
Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton.
Title: Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton.
Rab7b participation on the TLR4 (Toll-like receptor) endocytic pathway in Shiga toxin-associated Hemolytic Uremic Syndrome (HUS).
Title: Rab7b participation on the TLR4 (Toll-like receptor) endocytic pathway in Shiga toxin-associated Hemolytic Uremic Syndrome (HUS).
TBC1D5 is a GAP for Rab7b in the control of endosomal transport to the trans-Golgi.
Title: TBC1D5 controls the GTPase cycle of Rab7b.
study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B
Title: Rab7b modulates autophagic flux by interacting with Atg4B.
Authors determined the effects of T. suis soluble products (SPs) on Toll-like receptor-4 (TLR4)- In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling
Title: Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.
Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex.
Title: Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.
Rab7b is required for sortilin transport from endosomes to the TGN.
Title: Dynamics of Rab7b-dependent transport of sorting receptors.
Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production.
Title: Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association.
Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network.
Title: Rab7b controls trafficking from endosomes to the TGN.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1	PubMed
	gag	HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells	PubMed
	gag	HIV-1 Gag mainly remains in endosomes and co-localizes with endosomal protein Rab7 in the cycloheximide-treated cells	PubMed
capsid	gag	Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of toll-like receptor 9 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of megakaryocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	TAS Traceable Author Statement more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-7b

Names: Ras-related protein Rab-7

NP_001157994.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_001291768.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_796377.3

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_006711351.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_054192218.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164522.3 → NP_001157994.1 ras-related protein Rab-7b isoform a

See identical proteins and their annotated locations for NP_001157994.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AUXG01000006

Consensus CDS

CCDS73011.1

UniProtKB/Swiss-Prot

Q96AH8

Related

ENSP00000482499.1, ENST00000617070.5

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
NM_001304839.2 → NP_001291768.1 ras-related protein Rab-7b isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AUXG01000006

Consensus CDS

CCDS76258.1

UniProtKB/TrEMBL

A0A096LP44

Related

ENSP00000485386.1, ENST00000623893.1

Conserved Domains (1) summary

cd00154
Location:9 → 132

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
NM_177403.6 → NP_796377.3 ras-related protein Rab-7b isoform a

See identical proteins and their annotated locations for NP_796377.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AUXG01000006

Consensus CDS

CCDS73011.1

UniProtKB/Swiss-Prot

Q96AH8

Related

ENSP00000479762.1, ENST00000617991.4

Conserved Domains (1) summary

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

205976740..206003395 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006711288.5 → XP_006711351.1 ras-related protein Rab-7b isoform X1

Conserved Domains (2) summary

smart00175
Location:9 → 174

RAB; Rab subfamily of small GTPases

cd00154
Location:9 → 169

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)