U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CALHM4 calcium homeostasis modulator family member 4 [ Homo sapiens (human) ]

    Gene ID: 221301, updated on 9-Dec-2024

    Summary

    Official Symbol
    CALHM4provided by HGNC
    Official Full Name
    calcium homeostasis modulator family member 4provided by HGNC
    Primary source
    HGNC:HGNC:21094
    See related
    Ensembl:ENSG00000164451 AllianceGenome:HGNC:21094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM26D; C6orf78
    Summary
    Predicted to enable monoatomic cation channel activity. Predicted to be involved in ATP export and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta (RPKM 4.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CALHM4 in Genome Data Viewer
    Location:
    6q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (116529043..116561127)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (117712775..117744838)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (116850206..116882290)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17495 Neighboring gene CALHM6 antisense RNA 1 Neighboring gene calcium homeostasis modulator family member 6 Neighboring gene trafficking protein particle complex subunit 3L Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr6:116832513-116833094 Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene MPRA-validated peak6051 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24996 Neighboring gene RWD domain containing 1 Neighboring gene MPRA-validated peak6052 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24998 Neighboring gene uncharacterized LOC124901386 Neighboring gene radial spoke head component 4A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ32239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ATP export IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    calcium homeostasis modulator protein 4
    Names
    family with sequence similarity 26 member D
    protein FAM26D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256887.3NP_001243816.1  calcium homeostasis modulator protein 4 isoform a

      See identical proteins and their annotated locations for NP_001243816.1

      Status: VALIDATED

      Source sequence(s)
      AK056801, AK300309, AL121953, BC057769
      Consensus CDS
      CCDS59032.1
      UniProtKB/Swiss-Prot
      Q5JW98
      Related
      ENSP00000385836.1, ENST00000405399.5
      Conserved Domains (1) summary
      pfam14798
      Location:8114
      Ca_hom_mod; Calcium homeostasis modulator
    2. NM_001256888.3NP_001243817.1  calcium homeostasis modulator protein 4 isoform b

      See identical proteins and their annotated locations for NP_001243817.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK056801, AK300309, AL121953
      Consensus CDS
      CCDS59031.1
      UniProtKB/Swiss-Prot
      Q5JW98
      Related
      ENSP00000487169.1, ENST00000628083.1
      Conserved Domains (1) summary
      pfam14798
      Location:14113
      Ca_hom_mod; Calcium homeostasis modulator
    3. NM_001256889.3NP_001243818.1  calcium homeostasis modulator protein 4 isoform c

      See identical proteins and their annotated locations for NP_001243818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
      Source sequence(s)
      AK056801, AK300309, AL121953, DA855717
      Consensus CDS
      CCDS5109.1
      UniProtKB/TrEMBL
      B0QZ26
      Related
      ENSP00000409556.1, ENST00000452373.5
      Conserved Domains (1) summary
      pfam14798
      Location:171
      Ca_hom_mod; Calcium homeostasis modulator
    4. NM_001366078.2NP_001353007.1  calcium homeostasis modulator protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL121953
      Consensus CDS
      CCDS93991.1
      UniProtKB/Swiss-Prot
      B0QZ25, B0QZ27, B4DTQ0, Q5JW98, Q96MK0
      Related
      ENSP00000357585.3, ENST00000368596.4
      Conserved Domains (1) summary
      pfam14798
      Location:8257
      Ca_hom_mod; Calcium homeostasis modulator
    5. NM_153036.5NP_694581.1  calcium homeostasis modulator protein 4 isoform c

      See identical proteins and their annotated locations for NP_694581.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
      Source sequence(s)
      AK056801, AL121953, AY358252
      Consensus CDS
      CCDS5109.1
      UniProtKB/TrEMBL
      B0QZ26
      Related
      ENSP00000357586.2, ENST00000368597.6
      Conserved Domains (1) summary
      pfam14798
      Location:171
      Ca_hom_mod; Calcium homeostasis modulator

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      116529043..116561127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535562.3XP_011533864.1  calcium homeostasis modulator protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011533864.1

      Conserved Domains (1) summary
      pfam14798
      Location:25128
      Ca_hom_mod; Calcium homeostasis modulator
    2. XM_011535560.3XP_011533862.1  calcium homeostasis modulator protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011533862.1

      Conserved Domains (1) summary
      pfam14798
      Location:25128
      Ca_hom_mod; Calcium homeostasis modulator
    3. XM_017010390.2XP_016865879.1  calcium homeostasis modulator protein 4 isoform X1

    4. XM_017010391.2XP_016865880.1  calcium homeostasis modulator protein 4 isoform X2

    5. XM_011535561.3XP_011533863.1  calcium homeostasis modulator protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011533863.1

      Conserved Domains (1) summary
      pfam14798
      Location:25128
      Ca_hom_mod; Calcium homeostasis modulator
    6. XM_017010392.2XP_016865881.1  calcium homeostasis modulator protein 4 isoform X3

      Conserved Domains (1) summary
      pfam14798
      Location:25128
      Ca_hom_mod; Calcium homeostasis modulator
    7. XM_011535563.3XP_011533865.1  calcium homeostasis modulator protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011533865.1

      Conserved Domains (1) summary
      pfam14798
      Location:25128
      Ca_hom_mod; Calcium homeostasis modulator
    8. XM_011535564.2XP_011533866.1  calcium homeostasis modulator protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011533866.1

      Conserved Domains (1) summary
      pfam14798
      Location:25128
      Ca_hom_mod; Calcium homeostasis modulator

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      117712775..117744838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354525.1XP_054210500.1  calcium homeostasis modulator protein 4 isoform X3

    2. XM_054354523.1XP_054210498.1  calcium homeostasis modulator protein 4 isoform X3

    3. XM_054354521.1XP_054210496.1  calcium homeostasis modulator protein 4 isoform X1

    4. XM_054354522.1XP_054210497.1  calcium homeostasis modulator protein 4 isoform X2

    5. XM_054354524.1XP_054210499.1  calcium homeostasis modulator protein 4 isoform X3

    6. XM_054354527.1XP_054210502.1  calcium homeostasis modulator protein 4 isoform X3

    7. XM_054354526.1XP_054210501.1  calcium homeostasis modulator protein 4 isoform X3

    8. XM_054354528.1XP_054210503.1  calcium homeostasis modulator protein 4 isoform X3