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    Btbd9 BTB domain containing 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btbd9provided by RGD
    Official Full Name
    BTB domain containing 9provided by RGD
    Primary source
    RGD:1306975
    See related
    EnsemblRapid:ENSRNOG00000000540 AllianceGenome:RGD:1306975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in adult locomotory behavior; circadian behavior; and modulation of chemical synaptic transmission. Predicted to act upstream of or within several processes, including circadian sleep/wake cycle, non-REM sleep; long-term memory; and multicellular organismal-level iron ion homeostasis. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human BTBD9 (BTB domain containing 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 61.9), Thymus (RPKM 57.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btbd9 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (8287813..8645437, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (8286337..8645567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (8899286..9253936, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098952 Neighboring gene zinc finger AN1-type containing 3 Neighboring gene uncharacterized LOC134483873 Neighboring gene uncharacterized LOC120098951 Neighboring gene keratin-associated protein 5-1-like Neighboring gene uncharacterized LOC102548069 Neighboring gene glyoxalase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice. DeAndrade MP, et al. Hum Mol Genet, 2012 Sep 15. PMID 22678064, Free PMC Article
    2. Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice. DeAndrade MP, et al. PLoS One, 2012. PMID 22536397, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adult locomotory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within circadian behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within long-term memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within serotonin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 9
    Names
    BTB (POZ) domain containing 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013073.2 → NP_001013091.1  BTB/POZ domain-containing protein 9 isoform 1

      See identical proteins and their annotated locations for NP_001013091.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q5PQR3
      Related
      ENSRNOP00000000649.6, ENSRNOT00000000649.8
      Conserved Domains (4) summary
      smart00225
      Location:37 → 137
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14822
      Location:137 → 196
      BACK_BTBD9_like; BACK-like Domain C-terminal to BTB in BTB/POZ domain-containing protein 9 and similar proteins
      pfam00651
      Location:33 → 134
      BTB; BTB/POZ domain
      pfam00754
      Location:292 → 405
      F5_F8_type_C; F5/8 type C domain

    2. NM_001434573.1 → NP_001421502.1  BTB/POZ domain-containing protein 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q5PQR3

    3. NM_001434574.1 → NP_001421503.1  BTB/POZ domain-containing protein 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    4. NM_001434576.1 → NP_001421505.1  BTB/POZ domain-containing protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      8287813..8645437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256185.5 → XP_006256247.1  BTB/POZ domain-containing protein 9 isoform X3

      Conserved Domains (4) summary
      smart00225
      Location:37 → 137
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14822
      Location:137 → 196
      BACK_BTBD9_like; BACK-like Domain C-terminal to BTB in BTB/POZ domain-containing protein 9 and similar proteins
      pfam00651
      Location:33 → 134
      BTB; BTB/POZ domain
      pfam00754
      Location:292 → 405
      F5_F8_type_C; F5/8 type C domain

    2. XM_063279037.1 → XP_063135107.1  BTB/POZ domain-containing protein 9 isoform X1

    3. XM_063279038.1 → XP_063135108.1  BTB/POZ domain-containing protein 9 isoform X2

    4. XM_063279040.1 → XP_063135110.1  BTB/POZ domain-containing protein 9 isoform X6

    5. XM_039098534.2 → XP_038954462.1  BTB/POZ domain-containing protein 9 isoform X8

      Conserved Domains (2) summary
      cd18287
      Location:14 → 133
      BTB_POZ_BTBD9; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9)
      cd14822
      Location:137 → 235
      BACK_BTBD9; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9)

    6. XM_063279039.1 → XP_063135109.1  BTB/POZ domain-containing protein 9 isoform X5

    7. XM_039098533.2 → XP_038954461.1  BTB/POZ domain-containing protein 9 isoform X4

      Conserved Domains (2) summary
      cd18287
      Location:14 → 133
      BTB_POZ_BTBD9; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9)
      cd14822
      Location:137 → 235
      BACK_BTBD9; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9)

    8. XM_039098536.1 → XP_038954464.1  BTB/POZ domain-containing protein 9 isoform X7

      Conserved Domains (2) summary
      cd18287
      Location:14 → 133
      BTB_POZ_BTBD9; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9)
      cd14822
      Location:137 → 235
      BACK_BTBD9; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9)

    RNA

    1. XR_010060644.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQR3.1 GenPept UniProtKB/Swiss-Prot:Q5PQR3

    Gene LinkOut

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