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    She Src homology 2 domain containing E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sheprovided by RGD
    Official Full Name
    Src homology 2 domain containing Eprovided by RGD
    Primary source
    RGD:1583215
    See related
    EnsemblRapid:ENSRNOG00000020797 AllianceGenome:RGD:1583215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563897
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Orthologous to human SHE (Src homology 2 domain containing E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 144.7), Heart (RPKM 63.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See She in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177559636..177585485)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175262431..175287807)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189169691..189194934)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene uncharacterized LOC103691620 Neighboring gene interleukin 6 receptor Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene ATPase phospholipid transporting 8B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein E
    Names
    src homology 2 domain-containing transforming protein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433242.1 → NP_001420171.1  SH2 domain-containing adapter protein E

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5Y6C5, D4A529

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177559636..177585485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282723.1 → XP_063138793.1  SH2 domain-containing adapter protein E isoform X4

      UniProtKB/TrEMBL
      A6J6H9

    2. XM_063282722.1 → XP_063138792.1  SH2 domain-containing adapter protein E isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6C5
      Related
      ENSRNOP00000098855.1, ENSRNOT00000159550.1

    3. XM_063282721.1 → XP_063138791.1  SH2 domain-containing adapter protein E isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6C5
      Related
      ENSRNOP00000076781.2, ENSRNOT00000101897.2

    4. XM_001062249.8 → XP_001062249.1  SH2 domain-containing adapter protein E isoform X2

      Related
      ENSRNOP00000028225.6, ENSRNOT00000028225.8
      Conserved Domains (1) summary
      cd10391
      Location:399 → 496
      SH2_SHE; Src homology 2 domain found in SH2 domain-containing adapter protein E (SHE)
    Nucleotide Protein Strain
    Heading Accession and Version

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