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    Ablim3 actin binding LIM protein family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ablim3provided by RGD
    Official Full Name
    actin binding LIM protein family, member 3provided by RGD
    Primary source
    RGD:1565118
    See related
    EnsemblRapid:ENSRNOG00000019365 AllianceGenome:RGD:1565118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565118
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly; lamellipodium assembly; and positive regulation of protein targeting to mitochondrion. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in lamellipodium. Predicted to be active in glutamatergic synapse and stress fiber. Orthologous to human ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 106.2), Heart (RPKM 71.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ablim3 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57527917..57646936, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55256135..55376629, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57126534..57245965, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482948 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene actin filament associated protein 1-like 1 Neighboring gene uncharacterized LOC120098202 Neighboring gene uncharacterized LOC134483038

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. abLIM3 is a novel component of adherens junctions with actin-binding activity. Matsuda M, et al. Eur J Cell Biol, 2010 Nov. PMID 20709423
    2. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
    3. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
    4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding LIM protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191698.1 → NP_001178627.1  actin-binding LIM protein 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2K875, A0A8I6AVJ1
      Related
      ENSRNOP00000074499.2, ENSRNOT00000080365.3
      Conserved Domains (6) summary
      smart00153
      Location:648 → 683
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151 → 202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210 → 265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:274 → 647
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      57527917..57646936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277351.1 → XP_063133421.1  actin-binding LIM protein 3 isoform X6

      UniProtKB/TrEMBL
      A6IXJ1

    2. XM_063277347.1 → XP_063133417.1  actin-binding LIM protein 3 isoform X2

      UniProtKB/TrEMBL
      A6IXJ1

    3. XM_063277350.1 → XP_063133420.1  actin-binding LIM protein 3 isoform X5

      UniProtKB/TrEMBL
      A6IXJ1

    4. XM_063277349.1 → XP_063133419.1  actin-binding LIM protein 3 isoform X4

      UniProtKB/TrEMBL
      A6IXJ1
      Related
      ENSRNOP00000026227.4, ENSRNOT00000026227.8

    5. XM_063277348.1 → XP_063133418.1  actin-binding LIM protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IXJ1

    6. XM_063277353.1 → XP_063133423.1  actin-binding LIM protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3Y2
      Related
      ENSRNOP00000087213.2, ENSRNOT00000107734.2

    7. XM_063277352.1 → XP_063133422.1  actin-binding LIM protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ABY0

    8. XM_063277346.1 → XP_063133416.1  actin-binding LIM protein 3 isoform X1

      UniProtKB/TrEMBL
      A6IXJ1
    Nucleotide Protein Strain
    Heading Accession and Version

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