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    Usp35 ubiquitin specific peptidase 35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308834, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp35provided by RGD
    Official Full Name
    ubiquitin specific peptidase 35provided by RGD
    Primary source
    RGD:1565984
    See related
    EnsemblRapid:ENSRNOG00000024961 AllianceGenome:RGD:1565984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565984
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP35 (ubiquitin specific peptidase 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 65.4), Brain (RPKM 37.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Usp35 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (161037428..161061114, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151626195..151649926, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (162283866..162307610, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene asparaginyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC108349194 Neighboring gene GRB2-associated binding protein 2 Neighboring gene potassium channel tetramerization domain containing 21 Neighboring gene ALG8, alpha-1,3-glucosyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 35
    NP_001414738.1
    XP_038956997.1
    XP_038956999.1
    XP_038957000.1
    XP_038957001.1
    XP_038957002.1
    XP_038957003.1
    XP_038957004.1
    XP_038957007.1
    XP_063118829.1
    XP_063118830.1
    XP_063118837.1
    XP_063118838.1
    XP_063118839.1
    XP_063118842.1
    XP_063118843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427809.1NP_001414738.1  ubiquitin carboxyl-terminal hydrolase 35

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1M8S4
      Related
      ENSRNOP00000038242.5, ENSRNOT00000031161.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      161037428..161061114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101069.2XP_038956997.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

      Conserved Domains (1) summary
      cl02553
      Location:110582
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    2. XM_063262773.1XP_063118843.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    3. XM_039101071.2XP_038956999.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

      Conserved Domains (1) summary
      cl02553
      Location:46518
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_063262759.1XP_063118829.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    5. XM_039101076.2XP_038957004.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:10482
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    6. XM_039101074.2XP_038957002.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:10482
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    7. XM_063262769.1XP_063118839.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    8. XM_063262772.1XP_063118842.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    9. XM_039101072.2XP_038957000.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:10482
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    10. XM_063262767.1XP_063118837.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    11. XM_039101079.2XP_038957007.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:10482
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    12. XM_039101075.2XP_038957003.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:10482
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    13. XM_063262760.1XP_063118830.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    14. XM_063262768.1XP_063118838.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

    15. XM_039101073.2XP_038957001.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X3

      Conserved Domains (1) summary
      cl02553
      Location:10482
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...