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    Frem3 FRAS1 related extracellular matrix 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frem3provided by RGD
    Official Full Name
    FRAS1 related extracellular matrix 3provided by RGD
    Primary source
    RGD:1562701
    See related
    EnsemblRapid:ENSRNOG00000039152 AllianceGenome:RGD:1562701
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562701
    Summary
    Predicted to be involved in anatomical structure morphogenesis. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human FREM3 (FRAS1 related extracellular matrix 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 1.1), Testes (RPKM 0.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Frem3 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (44212842..44271137, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (27308469..27366771, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (30973329..31032331, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098602 Neighboring gene GRB2-associated binding protein 1 Neighboring gene SNF2 related chromatin remodeling ATPase 5 Neighboring gene glycophorin A Neighboring gene uncharacterized LOC134483633

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1. Kiyozumi D, et al. Matrix Biol, 2007 Jul. PMID 17462874
    2. Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development. Chiotaki R, et al. Gene Expr Patterns, 2007 Feb. PMID 17251066
    3. Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa. Petrou P, et al. Matrix Biol, 2007 Oct. PMID 17596926
    4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FRAS1-related extracellular matrix protein 3
    Names
    Fras1 related extracellular matrix protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191699.1 → NP_001178628.1  FRAS1-related extracellular matrix protein 3 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      D3ZYN7
      Related
      ENSRNOP00000056641.3, ENSRNOT00000059896.5
      Conserved Domains (2) summary
      pfam16184
      Location:1473 → 1614
      Cadherin_3; Cadherin-like
      cl02522
      Location:2004 → 2094
      Calx-beta; Calx-beta domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      44212842..44271137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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