Isl1 ISL LIM homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64444, updated on 9-Dec-2024

Summary

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Official Symbol: Isl1provided by RGD
Official Full Name: ISL LIM homeobox 1provided by RGD
Primary source: RGD:61957
See related: EnsemblRapid:ENSRNOG00000012556 AllianceGenome:RGD:61957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Isl-1; isl-1=homeobox
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; LIM domain binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 21.5), Adrenal (RPKM 20.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Isl1 in Genome Data Viewer

Location:: 2q14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (49813618..49823442, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (48079412..48090704, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (48488911..48501217, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes.
Title: Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes.
An in vitro model for the assessment of stem cell fate following implantation within the infarct microenvironment identifies ISL-1 expression as the strongest predictor of c-Kit(+) cardiac progenitor cells' therapeutic potential.
Title: An in vitro model for the assessment of stem cell fate following implantation within the infarct microenvironment identifies ISL-1 expression as the strongest predictor of c-Kit(+) cardiac progenitor cells' therapeutic potential.
Overexpression of LMX1B was associated with reduced cell apoptosis, whilst downregulation of LMX1B was associated with increased cell apoptosis in H-R RTEC.
Title: LIM homeobox transcription factor 1B is associated with pro-fibrotic components and apoptosis in hypoxia/reoxygenation renal tubular epithelial cells.
Isl1 is a key regulatory molecule in adult cardiac epithelial-to-mesenchymal transition.
Title: Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells.
Isl1-Lhx3, a LIM-complex mimicking fusion, induces a signature of motor neuron transcriptome & suppresses interneuron differentiation programs. An equimolar ratio of Isl1 & Lhx3 & the LIM domain of Lhx3 are crucial for this.
Title: Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.
expression of Islet-1 was found in NSC by immunocytochemical staining
Title: [Discovery of rat Islet-1 gene variant and its expression in NSC].
Subventricular zone neurons can be redirected from their normal migration route and directed towards other brain regions when they are infected with retroviruses encoding the developmentally important transcription factors islet-1 and neurogenin-2.
Title: Reprogramming of neonatal SVZ progenitors by islet-1 and neurogenin-2.
Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.
Title: Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.
data suggest the occurrence of a specific LIM-HD pituitary code and designate the GnRH-R gene as the first identified transcriptional target of Isl-1 in the anterior pituitary
Title: The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC186328P1 (e-PCR)
- UniSTS:271699

RH141578 (e-PCR)
- UniSTS:223572

D10Bir8 (e-PCR), detects polymorphism
- UniSTS:141487

Isl1 (e-PCR), detects polymorphism
- UniSTS:547558

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables LIM domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in atrial septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrial septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in cardiac cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in endocardial cushion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in innervation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in neuron fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system neuron axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in peripheral nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal system development	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in pituitary gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of granulocyte colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 alpha production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of secondary heart field cardioblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in retinal ganglion cell axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	ISO Inferred from Sequence Orthology more info
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in secondary heart field specification	ISO Inferred from Sequence Orthology more info
involved_in sensory system development	IEA Inferred from Electronic Annotation more info
involved_in sensory system development	ISO Inferred from Sequence Orthology more info
involved_in sinoatrial node cell development	IEA Inferred from Electronic Annotation more info
involved_in sinoatrial node cell development	ISO Inferred from Sequence Orthology more info
involved_in spinal cord motor neuron cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	IEA Inferred from Electronic Annotation more info
involved_in trigeminal nerve development	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in visceral motor neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visceral motor neuron differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin gene enhancer protein ISL-1

Names: ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain 1; isl-1 homeobox; islet-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017339.3 → NP_059035.3 insulin gene enhancer protein ISL-1

See identical proteins and their annotated locations for NP_059035.3

Status: PROVISIONAL

Source sequence(s)

S69329

UniProtKB/Swiss-Prot

P61374

UniProtKB/TrEMBL

A0A8L2Q8Q3, A6I5T7

Related

ENSRNOP00000076523.2, ENSRNOT00000117391.2

Conserved Domains (3) summary

cd09366
Location:17 → 71

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09374
Location:79 → 133

LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family

smart00389
Location:181 → 237

HOX; Homeodomain