U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mt-Co1 cytochrome c oxidase I, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26195, updated on 14-Nov-2024

    Summary

    Official Symbol
    mt-Co1provided by RGD
    Official Full Name
    cytochrome c oxidase I, mitochondrialprovided by RGD
    Primary source
    RGD:621871
    See related
    AllianceGenome:RGD:621871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus (strain: BN/SsNHsdMCW)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    COI; COX1
    Summary
    Predicted to enable heme binding activity and metal ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in several processes, including response to copper ion; response to electrical stimulus; and response to hypoxia. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Used to study hepatocellular carcinoma. Biomarker of Parkinsonism. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See mt-Co1 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (5323..6867)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (5323..6867)

    Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene tRNA-Cys Neighboring gene tRNA-Tyr Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene COXII

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    • Co1; Cox1

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cytochrome-c oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex IV ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase subunit I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001665.2 Reference assembly

      Range
      5323..6867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_665631.1 cytochrome c oxidase subunit I (mitochondrion) [Rattus norvegicus]

      See identical proteins and their annotated locations for YP_665631.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P05503
      UniProtKB/TrEMBL
      Q06QA9, Q06QK0, Q8HIC9
      Conserved Domains (2) summary
      MTH00153
      Location:4507
      COX1; cytochrome c oxidase subunit I; Provisional
      pfam00115
      Location:14460
      COX1; Cytochrome C and Quinol oxidase polypeptide I