Adipor2 adiponectin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adipor2provided by RGD
Official Full Name: adiponectin receptor 2provided by RGD
Primary source: RGD:1307891
See related: EnsemblRapid:ENSRNOG00000007990 AllianceGenome:RGD:1307891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable adipokinetic hormone receptor activity; adiponectin binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of hepatic stellate cell migration; positive regulation of D-glucose import; and response to fructose. Predicted to be active in plasma membrane. Biomarker of end stage renal disease; glucose metabolism disease (multiple); obesity; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 685.2), Liver (RPKM 620.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (154195440..154261141, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (152524604..152588848, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (151412135..151480108, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crosstalk relationship between adiponectin receptors, PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic WKYs.
Title: Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs.
The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
Title: The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
In a model of NAFLD, Adipor2 was primarily expressed in the cytoplasm of hepatocytes.
Title: Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD.
Adipo R2 expression in kidney is increased in chronic renal failure
Title: Changes of adiponectin and its receptors in rats following chronic renal failure.
Adiponectin functions as a promoter of Adiponectin functions as a promoter of salivary secretion in rat submandibular glands via activation of Adiponectin receptors, AMPK, and paracellular permeability.
Title: Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling.
AdipoR1 and AdipoR2 gene expression is regulated by thyroid hormones in hypo- and hyperthyroidism.
Title: AdipoR1 and AdipoR2 gene expression are regulated by thyroid hormones in adipose tissue.
The results demonstrate that human biosynthetic insulin down-regulates both AdipoR1 and AdipoR2 mRNAs levels in a biphasic manner in L6 and PAC1 cells.
Title: Insulin-regulated expression of adiponectin receptors in muscle and fat cells.
Telmisartan upregulates myocardial expression of Adipor2 in type 2 diabetic rats.
Title: Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats.
the effects of Caloric restriction on adiposity and gene expression of adiponectin, its receptors (AdipoR2 in adipose tissue and in isolated adipocytes
Title: Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats.
AdipoR2 and insulin receptor substrate isoforms might be crucially important regulators for the synthesis and oxidation of fatty acids in the liver of Nonalcoholic steatohepatitis
Title: Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model.

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Markers

Adipor2 (e-PCR), detects polymorphism
- UniSTS:471067

RH138934 (e-PCR)
- UniSTS:221020

BM386739 (e-PCR)
- UniSTS:261527

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adiponectin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hepatic stellate cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in vascular wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adiponectin receptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.