Slc17a4 solute carrier family 17 (sodium phosphate), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc17a4provided by MGI
Official Full Name: solute carrier family 17 (sodium phosphate), member 4provided by MGI
Primary source: MGI:MGI:2442850
See related: Ensembl:ENSMUSG00000021336 AllianceGenome:MGI:2442850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9130214H05Rik
Summary: Enables urate transmembrane transporter activity. Predicted to be involved in monoatomic anion transport and sodium-dependent phosphate transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; liver; and spinal cord mantle layer. Orthologous to human SLC17A4 (solute carrier family 17 member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 15.9), large intestine adult (RPKM 13.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 9.98 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (24081862..24098992, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (23897879..23915009, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables urate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in urate transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable small intestine urate exporter

Names: putative small intestine sodium-dependent phosphate transport protein; solute carrier family 17 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177016.3 → NP_795990.2 probable small intestine urate exporter

See identical proteins and their annotated locations for NP_795990.2

Status: VALIDATED

Source sequence(s)

AK033669, AK050272, AK162320

Consensus CDS

CCDS49221.1

UniProtKB/Swiss-Prot

B9EJP0, Q5NCM1

Related

ENSMUSP00000021769.10, ENSMUST00000021769.16

Conserved Domains (2) summary

cd06174
Location:98 → 475

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:27 → 486

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

24081862..24098992 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516694.1 → XP_006516757.1 probable small intestine urate exporter isoform X2

Conserved Domains (1) summary

cd17318
Location:37 → 421

MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters
XM_006516695.1 → XP_006516758.1 probable small intestine urate exporter isoform X3

Conserved Domains (1) summary

cd17318
Location:37 → 418

MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters
XM_006516693.1 → XP_006516756.1 probable small intestine urate exporter isoform X1

UniProtKB/TrEMBL

A0A2C9F2D4

Related

ENSMUSP00000106037.4, ENSMUST00000110407.4

Conserved Domains (1) summary

cd17318
Location:37 → 448

MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters
XM_006516700.3 → XP_006516763.1 probable small intestine urate exporter isoform X5

Conserved Domains (1) summary

TIGR00894
Location:2 → 283

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
XM_006516697.3 → XP_006516760.1 probable small intestine urate exporter isoform X4

See identical proteins and their annotated locations for XP_006516760.1

Conserved Domains (1) summary

cl28910
Location:37 → 370

MFS; Major Facilitator Superfamily
XM_006516696.1 → XP_006516759.1 probable small intestine urate exporter isoform X4

See identical proteins and their annotated locations for XP_006516759.1

Conserved Domains (1) summary

cl28910
Location:37 → 370

MFS; Major Facilitator Superfamily