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    Cimip2a ciliary microtubule inner protein 2A [ Mus musculus (house mouse) ]

    Gene ID: 68222, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cimip2aprovided by MGI
    Official Full Name
    ciliary microtubule inner protein 2Aprovided by MGI
    Primary source
    MGI:MGI:3605773
    See related
    Ensembl:ENSMUSG00000026969 AllianceGenome:MGI:3605773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam166a; 4931415M17
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human CIMIP2A (ciliary microtubule inner protein 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 147.1) and liver E14 (RPKM 8.6) See more
    Orthologs
    human all
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    Genomic context

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    See Cimip2a in Genome Data Viewer
    Location:
    2 A3; 2 17.08 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25104382..25112293)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25214699..25222281)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3362 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25052129-25052238 Neighboring gene torsin family 4, member A Neighboring gene negative elongation factor complex member B Neighboring gene predicted gene, 22572 Neighboring gene sperm tail PG rich repeat containing 3 Neighboring gene tubulin, beta 4B class IVB Neighboring gene STARR-seq mESC enhancer starr_03963 Neighboring gene solute carrier family 34 (sodium phosphate), member 3 Neighboring gene ring finger protein 224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
    2. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary microtubule inner protein 2A
    Names
    4931415M17 mRNA
    family with sequence similarity 166, member A
    protein FAM166A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421893.1 → NP_001408822.1  ciliary microtubule inner protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL732309
      UniProtKB/Swiss-Prot
      Q9D4K5

    2. NM_001421894.1 → NP_001408823.1  ciliary microtubule inner protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL732309
      UniProtKB/Swiss-Prot
      Q9D4K5

    3. NM_001421895.1 → NP_001408824.1  ciliary microtubule inner protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL732309
      UniProtKB/Swiss-Prot
      Q9D4K5

    4. NM_001421896.1 → NP_001408825.1  ciliary microtubule inner protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL732309
      UniProtKB/Swiss-Prot
      Q9D4K5

    5. NM_001421897.1 → NP_001408826.1  ciliary microtubule inner protein 2A isoform a

      Status: VALIDATED

      Source sequence(s)
      AL732309
      UniProtKB/Swiss-Prot
      Q9D4K5

    6. NM_001421898.1 → NP_001408827.1  ciliary microtubule inner protein 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AL732309

    7. NM_001421900.1 → NP_001408829.1  ciliary microtubule inner protein 2A isoform c

      Status: VALIDATED

      Source sequence(s)
      AL732309

    8. NM_026624.4 → NP_080900.1  ciliary microtubule inner protein 2A isoform a

      See identical proteins and their annotated locations for NP_080900.1

      Status: VALIDATED

      Source sequence(s)
      AL732309
      Consensus CDS
      CCDS15752.1
      UniProtKB/Swiss-Prot
      Q9D4K5
      Related
      ENSMUSP00000028346.4, ENSMUST00000028346.4
      Conserved Domains (1) summary
      pfam10629
      Location:13 → 45
      DUF2475; Protein of unknown function (DUF2475)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25104382..25112293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162515.1 → XP_036018408.1  ciliary microtubule inner protein 2A isoform X4

    2. XM_006498265.4 → XP_006498328.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_006498328.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)

    3. XM_006498268.5 → XP_006498331.1  ciliary microtubule inner protein 2A isoform X2

      See identical proteins and their annotated locations for XP_006498331.1

      UniProtKB/Swiss-Prot
      Q9D4K5
      Conserved Domains (1) summary
      pfam10629
      Location:13 → 45
      DUF2475; Protein of unknown function (DUF2475)

    4. XM_006498266.4 → XP_006498329.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_006498329.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)

    5. XM_030252011.2 → XP_030107871.1  ciliary microtubule inner protein 2A isoform X3

      Conserved Domains (1) summary
      pfam10629
      Location:11 → 36
      DUF2475; Protein of unknown function (DUF2475)

    6. XM_006498267.4 → XP_006498330.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_006498330.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)

    7. XM_011239161.3 → XP_011237463.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011237463.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)

    8. XM_030252005.2 → XP_030107865.1  ciliary microtubule inner protein 2A isoform X2

      UniProtKB/Swiss-Prot
      Q9D4K5
      Conserved Domains (1) summary
      pfam10629
      Location:13 → 45
      DUF2475; Protein of unknown function (DUF2475)

    9. XM_030252012.2 → XP_030107872.1  ciliary microtubule inner protein 2A isoform X4

    10. XM_011239162.3 → XP_011237464.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011237464.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)

    11. XM_030252010.2 → XP_030107870.1  ciliary microtubule inner protein 2A isoform X2

      UniProtKB/Swiss-Prot
      Q9D4K5
      Conserved Domains (1) summary
      pfam10629
      Location:13 → 45
      DUF2475; Protein of unknown function (DUF2475)

    12. XM_030252015.2 → XP_030107875.1  ciliary microtubule inner protein 2A isoform X4

    13. XM_011239164.3 → XP_011237466.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011237466.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)

    14. XM_030252014.2 → XP_030107874.1  ciliary microtubule inner protein 2A isoform X4

    15. XM_030252013.2 → XP_030107873.1  ciliary microtubule inner protein 2A isoform X4

    16. XM_011239165.3 → XP_011237467.1  ciliary microtubule inner protein 2A isoform X1

      See identical proteins and their annotated locations for XP_011237467.1

      Conserved Domains (1) summary
      pfam10629
      Location:13 → 55
      DUF2475; Protein of unknown function (DUF2475)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4K5.1 GenPept UniProtKB/Swiss-Prot:Q9D4K5

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