Dync1i1 dynein cytoplasmic 1 intermediate chain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dync1i1provided by MGI
Official Full Name: dynein cytoplasmic 1 intermediate chain 1provided by MGI
Primary source: MGI:MGI:107743
See related: Ensembl:ENSMUSG00000029757 AllianceGenome:MGI:107743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DIC; IC74; DHIC-1; Dncic1; DH IC-1
Summary: Enables dynein light chain binding activity. Predicted to be involved in vesicle transport along microtubule. Predicted to be located in several cellular components, including axon cytoplasm; cytoplasmic vesicle; and spindle pole. Predicted to be part of cytoplasmic dynein complex. Is expressed in several structures, including central nervous system; genitourinary system; limb; peripheral nervous system ganglion; and skeletal musculature. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 41.3), cerebellum adult (RPKM 34.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 2.26 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (5725772..6028030)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (5725600..6028039)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SQSTM1 is required for proper dynein motility and trafficking along microtubules.
Title: Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.
results indicate that LIS1 is a previously unrecognized regulator of osteoclast formation, microtubule organization, and lysosomal secretion by virtue of its ability to modulate dynein function and Plekhm1
Title: LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.
An all-atom model structure is obtained for dynein high-affinity form of microtubule (MT) binding domain bound to MT by an anisotropic network model, protein-protein docking, and molecular dynamics simulation
Title: How does a registry change in dynein's coiled-coil stalk drive binding of dynein to microtubules?
These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system.
Title: Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
Study found six different Dync1i1 splicing pattern in mice.
Title: Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

37.MMHAP14FLE4.seq (e-PCR)
- UniSTS:124217

RH46992 (e-PCR)
- UniSTS:5464

Dync1i1 (e-PCR), detects polymorphism
- UniSTS:478865

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in piccolo-bassoon transport vesicle	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytoplasmic dynein 1 intermediate chain 1

Names: Dynein intermediate chain 1, cytosolic (DH IC-1) (Cytoplasmic dynein intermediate chain 1); dynein, cytoplasmic, intermediate chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191023.2 → NP_001177952.1 cytoplasmic dynein 1 intermediate chain 1 isoform 2

See identical proteins and their annotated locations for NP_001177952.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/TrEMBL

D6Q0F3

Conserved Domains (4) summary

COG2319
Location:183 → 595

WD40; WD40 repeat [General function prediction only]

pfam11540
Location:127 → 153

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:326 → 365

7WD40; WD40 repeat [structural motif]

cl02567
Location:263 → 586

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001191025.2 → NP_001177954.1 cytoplasmic dynein 1 intermediate chain 1 isoform 4

See identical proteins and their annotated locations for NP_001177954.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

Consensus CDS

CCDS57408.1

UniProtKB/Swiss-Prot

O88485

Related

ENSMUSP00000111216.2, ENSMUST00000115554.4

Conserved Domains (4) summary

COG2319
Location:166 → 578

WD40; WD40 repeat [General function prediction only]

pfam11540
Location:110 → 136

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:309 → 348

7WD40; WD40 repeat [structural motif]

cl02567
Location:246 → 569

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001191026.2 → NP_001177955.1 cytoplasmic dynein 1 intermediate chain 1 isoform 3

See identical proteins and their annotated locations for NP_001177955.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1. Variants 3 and 8 both encode the same isoform (3).

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

Consensus CDS

CCDS57409.1

UniProtKB/TrEMBL

Q3TYJ3

Related

ENSMUSP00000111218.2, ENSMUST00000115556.8

Conserved Domains (3) summary

sd00039
Location:318 → 357

7WD40; WD40 repeat [structural motif]

pfam11540
Location:119 → 145

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:255 → 578

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001191027.2 → NP_001177956.1 cytoplasmic dynein 1 intermediate chain 1 isoform 5

See identical proteins and their annotated locations for NP_001177956.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region and lacks a coding exon compared to variant 1. The resulting protein (isoform 5) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/TrEMBL

D6Q0F4

Conserved Domains (4) summary

COG2319
Location:155 → 567

WD40; WD40 repeat [General function prediction only]

pfam11540
Location:99 → 125

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:298 → 337

7WD40; WD40 repeat [structural motif]

cl02567
Location:235 → 558

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001409608.1 → NP_001396537.1 cytoplasmic dynein 1 intermediate chain 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/Swiss-Prot

O88485, O88486, Q80W09
NM_001409609.1 → NP_001396538.1 cytoplasmic dynein 1 intermediate chain 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/Swiss-Prot

O88485, O88486, Q80W09
NM_001409610.1 → NP_001396539.1 cytoplasmic dynein 1 intermediate chain 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/TrEMBL

Q3TYJ3
NM_001409611.1 → NP_001396540.1 cytoplasmic dynein 1 intermediate chain 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/TrEMBL

D3Z0M6

Related

ENSMUSP00000111217.2, ENSMUST00000115555.8
NM_001409612.1 → NP_001396541.1 cytoplasmic dynein 1 intermediate chain 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

UniProtKB/TrEMBL

D3Z0M6
NM_001409613.1 → NP_001396542.1 cytoplasmic dynein 1 intermediate chain 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC023175, AC023286, AC034254, AC162178
NM_010063.5 → NP_034193.2 cytoplasmic dynein 1 intermediate chain 1 isoform 1

See identical proteins and their annotated locations for NP_034193.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, and 7 all encode the same isoform (1).

Source sequence(s)

AC023175, AC023286, AC034254, AC162178

Consensus CDS

CCDS19903.1

UniProtKB/Swiss-Prot

O88485, O88486, Q80W09

Related

ENSMUSP00000111221.4, ENSMUST00000115559.10

Conserved Domains (3) summary

sd00039
Location:329 → 368

7WD40; WD40 repeat [structural motif]

pfam11540
Location:130 → 156

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:266 → 589

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...