Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a5provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5provided by MGI
Primary source: MGI:MGI:1298205
See related: Ensembl:ENSMUSG00000040010 AllianceGenome:MGI:1298205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TA1; LAT1; 4F2LC; Gm42049; D0H16S474E
Summary: Enables L-amino acid transmembrane transporter activity. Involved in L-leucine transport. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; cochlea; early conceptus; limb; and reproductive system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in genital fat pad adult (RPKM 202.2), ovary adult (RPKM 100.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (122607885..122634425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (121881146..121907686, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.
Title: TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.
Cancer-associated fibroblasts-derived exosomal METTL3 promotes the proliferation, invasion, stemness and glutaminolysis in non-small cell lung cancer cells by eliciting SLC7A5 m6A modification.
Title: Cancer-associated fibroblasts-derived exosomal METTL3 promotes the proliferation, invasion, stemness and glutaminolysis in non-small cell lung cancer cells by eliciting SLC7A5 m6A modification.
Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine.
Title: Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine.
FBW7/GSK3beta mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Title: FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer.
Title: Targeting glutamine metabolic reprogramming of SLC7A5 enhances the efficacy of anti-PD-1 in triple-negative breast cancer.
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models.
Title: Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models.
LAT1 enables T cell activation under inflammatory conditions.
Title: LAT1 enables T cell activation under inflammatory conditions.
LAT1 expression influences Paneth cell number and tumor development in Apc[Min/+] mice.
Title: LAT1 expression influences Paneth cell number and tumor development in Apc(Min/+) mice.
Large neutral amino acid levels tune perinatal neuronal excitability and survival.
Title: Large neutral amino acid levels tune perinatal neuronal excitability and survival.
SRC2 controls CD4[+] T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.
Title: SRC2 controls CD4(+) T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc7a5 (e-PCR), detects polymorphism
- UniSTS:547361

AB017189 (e-PCR)
- UniSTS:163448

Lat (e-PCR), detects polymorphism
- UniSTS:526750

Car5a (e-PCR), detects polymorphism
- UniSTS:141226

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-tryptophan transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-tryptophan transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables aromatic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thyroid hormone transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transport	IEA Inferred from Electronic Annotation more info
involved_in L-histidine transport	ISO Inferred from Sequence Orthology more info
involved_in L-leucine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in L-tryptophan transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-tryptophan transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in alanine transport	IEA Inferred from Electronic Annotation more info
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to L-arginine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in isoleucine transport	IEA Inferred from Electronic Annotation more info
involved_in isoleucine transport	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in methionine transport	IEA Inferred from Electronic Annotation more info
involved_in methionine transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in phenylalanine transport	IEA Inferred from Electronic Annotation more info
involved_in phenylalanine transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-leucine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in proline transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	ISO Inferred from Sequence Orthology more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	ISO Inferred from Sequence Orthology more info
involved_in valine transport	IEA Inferred from Electronic Annotation more info
involved_in valine transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of amino acid transport complex	ISO Inferred from Sequence Orthology more info
part_of amino acid transport complex	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: large neutral amino acids transporter small subunit 1

Names: 4F2 LC; 4F2 light chain; L-type amino acid transporter 1; solute carrier family 7 member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.