Glra1 glycine receptor, alpha 1 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glra1provided by MGI
Official Full Name: glycine receptor, alpha 1 subunitprovided by MGI
Primary source: MGI:MGI:95747
See related: Ensembl:ENSMUSG00000000263 AllianceGenome:MGI:95747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ot; spd; nmf11; spasmodic; oscillator
Summary: Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in glycinergic synaptic transmission; inhibitory postsynaptic potential; and response to alcohol. Acts upstream of or within several processes, including adult walking behavior; neuronal action potential; and regulation of respiratory gaseous exchange by nervous system process. Located in several cellular components, including external side of plasma membrane; inhibitory synapse; and postsynaptic membrane. Is active in glycinergic synapse. Is expressed in brain; brainstem; rhombomere 2; rhombomere 4; and spinal cord. Used to study hyperekplexia and hyperekplexia 1. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 5.8), CNS E11.5 (RPKM 0.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 33.12 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (55405065..55499024, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (55514239..55608198, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice.
Title: Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice.
Analgesic action of adenosine A1 receptor involves the dephosphorylation of glycine receptor alpha1(ins) subunit in spinal dorsal horn of mice.
Title: Analgesic action of adenosine A1 receptor involves the dephosphorylation of glycine receptor α1(ins) subunit in spinal dorsal horn of mice.
Functional expression of glycine receptors in DRG neurons of mice.
Title: Functional expression of glycine receptors in DRG neurons of mice.
These findings suggest that spinal alpha1 GlyR is a potential target for cannabinoid analgesia in chronic inflammatory pain.
Title: Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia.
The results of this study suggested that the Glra1 activation can regulate receptor diffusion and cluster size at inhibitory synapses in mature stage, providing not only new insights into the postsynaptic mechanism of shifting inhibitory neurotransmission but also the inhibitory synaptic plasticity in mature nervous system
Title: Activation-Dependent Rapid Postsynaptic Clustering of Glycine Receptors in Mature Spinal Cord Neurons.
Glra1 receptor Beta8-Beta9 loop is an essential regulator of conformational rearrangements in ion channel opening and closing.
Title: Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease.
Absence of GlyRalpha1 input unmasked a serial and a direct feedforward GABAAergic modulation in PV5 RGCs, reflecting a complex interaction between glycinergic and GABAAergic inhibition.
Title: Adeno-associated virus-RNAi of GlyRα1 and characterization of its synapse-specific inhibition in OFF alpha transient retinal ganglion cells.
Results suggest an important function of alpha1 GlyR on sedative effects of ethanol and confirms the role of KK385-386 residues in these effects
Title: Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation.
Meanwhile, neonatal incision significantly decreased the density of tonic GlyR-mediated current only in the presumed glutamatergic population during adulthood.
Title: Deficits in glycinergic inhibition within adult spinal nociceptive circuits after neonatal tissue damage.
Histamine is an inverse agonist at strychnine sensitive glycine receptors.
Title: New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Spontaneous (5) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Glra1 (e-PCR), detects polymorphism
- UniSTS:143222

NoName (e-PCR)
- UniSTS:491430

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly glycine-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly glycine-gated chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly glycine-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables extracellularly glycine-gated chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables extracellularly glycine-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables glycine binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables taurine binding	ISO Inferred from Sequence Orthology more info
enables taurine binding	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmission of nerve impulse	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling posture	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alcohol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within righting reflex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synaptic transmission, glycinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glycinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glycinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glycine receptor subunit alpha-1

Names: glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290821.1 → NP_001277750.1 glycine receptor subunit alpha-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001277750.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK078258, AL596207, AY129229

Consensus CDS

CCDS70190.1

UniProtKB/Swiss-Prot

Q5NCT8, Q64018, Q64019, Q9R0Y6, Q9R0Y7

Related

ENSMUSP00000075032.5, ENSMUST00000075603.5

Conserved Domains (1) summary

TIGR00860
Location:7 → 446

LIC; Cation transporter family protein
NM_020492.4 → NP_065238.2 glycine receptor subunit alpha-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_065238.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK078258, AL596207, AY129229

Consensus CDS

CCDS24715.1

UniProtKB/TrEMBL

Q5NCT9

Related

ENSMUSP00000099777.4, ENSMUST00000102716.10

Conserved Domains (1) summary

TIGR00860
Location:7 → 438

LIC; Cation transporter family protein