Art4 ADP-ribosyltransferase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Art4provided by MGI
Official Full Name: ADP-ribosyltransferase 4provided by MGI
Primary source: MGI:MGI:1202710
See related: Ensembl:ENSMUSG00000030217 AllianceGenome:MGI:1202710
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DO; DOK1; ARTC4; 4432404K01Rik
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be located in plasma membrane and side of membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; integumental system; liver; and sensory organ. Orthologous to human ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14.5 (RPKM 15.6), liver E14 (RPKM 12.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 66.72 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (136825449..136834598, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (136848451..136857600, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein-arginine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ecto-ADP-ribosyltransferase 4

Names: ADP-ribosyltransferase C2 and C3 toxin-like 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4; mono(ADP-ribosyl)transferase 4

NP_080915.1

EC 2.4.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026639.2 → NP_080915.1 ecto-ADP-ribosyltransferase 4 precursor

See identical proteins and their annotated locations for NP_080915.1

Status: VALIDATED

Source sequence(s)

AK019467

Consensus CDS

CCDS20658.1

UniProtKB/Swiss-Prot

Q80VB5, Q80W56, Q9CRA0

Related

ENSMUSP00000032341.3, ENSMUST00000032341.3

Conserved Domains (1) summary

cl00173
Location:35 → 256

VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...