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    Slc35b3 solute carrier family 35, member B3 [ Mus musculus (house mouse) ]

    Gene ID: 108652, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc35b3provided by MGI
    Official Full Name
    solute carrier family 35, member B3provided by MGI
    Primary source
    MGI:MGI:1913978
    See related
    Ensembl:ENSMUSG00000021432 AllianceGenome:MGI:1913978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-19; PABST2; PAPST2; 4921526O06Rik
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 5'-adenylyl sulfate transmembrane transport and peptidyl-tyrosine sulfation. Located in mitochondrion. Is active in Golgi membrane and trans-Golgi network. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human SLC35B3 (solute carrier family 35 member B3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.6), limb E14.5 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35b3 in Genome Data Viewer
    Location:
    13 A3.3; 13 18.61 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (39116112..39144855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38932132..38960879, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34252 Neighboring gene DNA polymerase epsilon subunit 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_34253 Neighboring gene STARR-seq mESC enhancer starr_34254 Neighboring gene STARR-seq mESC enhancer starr_34255 Neighboring gene STARR-seq mESC enhancer starr_34256 Neighboring gene predicted gene, 46392 Neighboring gene RIKEN cDNA 5033403F01 gene Neighboring gene STARR-seq mESC enhancer starr_34258 Neighboring gene STARR-seq mESC enhancer starr_34259 Neighboring gene STARR-seq mESC enhancer starr_34260 Neighboring gene STARR-seq mESC enhancer starr_34261 Neighboring gene STARR-seq mESC enhancer starr_34262 Neighboring gene predicted gene 3509 Neighboring gene STARR-seq mESC enhancer starr_34265 Neighboring gene predicted gene, 32243

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells. Sasaki N, et al. PLoS One, 2009 Dec 11. PMID 20011239, Free PMC Article
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2]
      Title: The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5'-adenylyl sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine sulfation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine 3'-phospho 5'-phosphosulfate transporter 2
    Names
    PAPS transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170430.2 → NP_001163901.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_001163901.1

      Status: VALIDATED

      Source sequence(s)
      AC125223
      Consensus CDS
      CCDS26466.1
      UniProtKB/Swiss-Prot
      Q922Q5
      UniProtKB/TrEMBL
      F8WGD7
      Related
      ENSMUSP00000126016.2, ENSMUST00000167513.3
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 339
      UAA; UAA transporter family

    2. NM_001170431.3 → NP_001163902.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125223
      Consensus CDS
      CCDS26466.1
      UniProtKB/Swiss-Prot
      Q922Q5
      UniProtKB/TrEMBL
      F8WGD7
      Related
      ENSMUSP00000021870.5, ENSMUST00000021870.12
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 339
      UAA; UAA transporter family

    3. NM_001403012.1 → NP_001389941.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125223

    4. NM_001403013.1 → NP_001389942.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125223

    5. NM_001403014.1 → NP_001389943.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125223

    6. NM_001403015.1 → NP_001389944.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125223

    7. NM_001403016.1 → NP_001389945.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125223
      UniProtKB/Swiss-Prot
      Q922Q5

    8. NM_001403017.1 → NP_001389946.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125223

    9. NM_134060.5 → NP_598821.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_598821.1

      Status: VALIDATED

      Source sequence(s)
      AC125223
      Consensus CDS
      CCDS26466.1
      UniProtKB/Swiss-Prot
      Q922Q5
      UniProtKB/TrEMBL
      F8WGD7
      Related
      ENSMUSP00000153046.2, ENSMUST00000225432.2
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 339
      UAA; UAA transporter family

    RNA

    1. NR_175328.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125223

    2. NR_175329.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125223

    3. NR_175330.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125223

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      39116112..39144855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247124.1 → XP_030102984.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

      Conserved Domains (1) summary
      pfam08449
      Location:92 → 161
      UAA; UAA transporter family

    RNA

    1. XR_003950408.2 RNA Sequence

    2. XR_001780746.3 RNA Sequence

    3. XR_004937924.1 RNA Sequence

    4. XR_001780745.3 RNA Sequence

    5. XR_004937925.1 RNA Sequence

    6. XR_003950410.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922Q5.1 GenPept UniProtKB/Swiss-Prot:Q922Q5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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