Padi1 peptidyl arginine deiminase, type I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Padi1provided by MGI
Official Full Name: peptidyl arginine deiminase, type Iprovided by MGI
Primary source: MGI:MGI:1338893
See related: Ensembl:ENSMUSG00000025329 AllianceGenome:MGI:1338893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdi1
Summary: Predicted to enable calcium ion binding activity and protein-arginine deiminase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in blastocyst; early embryo; and oocyte. Orthologous to human PADI1 (peptidyl arginine deiminase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 3.0) and 1 other tissue See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 D3; 4 72.62 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (140540292..140573089, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (140812981..140845778, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H1R54 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AR3 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R17 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R2 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R26 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H3R8 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables histone H4R3 arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine deiminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine deiminase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine deiminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine deiminase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: protein-arginine deiminase type-1

Names: PAD type I; PROTEIN-ARGININE DEIMINASE TYPE I (PEPTIDYLARGININE DEIMINASE I); Pad type 1; peptidylarginine deiminase I

NP_035189.1

EC 3.5.3.15

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011059.2 → NP_035189.1 protein-arginine deiminase type-1

See identical proteins and their annotated locations for NP_035189.1

Status: PROVISIONAL

Source sequence(s)

AL807805

Consensus CDS

CCDS18856.1

UniProtKB/Swiss-Prot

Q9Z185

UniProtKB/TrEMBL

Q544I4

Related

ENSMUSP00000026378.4, ENSMUST00000026378.4

Conserved Domains (3) summary

pfam03068
Location:283 → 659

PAD; Protein-arginine deiminase (PAD)

pfam08526
Location:1 → 113

PAD_N; Protein-arginine deiminase (PAD) N-terminal domain

pfam08527
Location:115 → 260

PAD_M; Protein-arginine deiminase (PAD) middle domain