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    Tuba1b tubulin, alpha 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500929, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tuba1bprovided by RGD
    Official Full Name
    tubulin, alpha 1Bprovided by RGD
    Primary source
    RGD:1565476
    See related
    EnsemblRapid:ENSRNOG00000072536 AllianceGenome:RGD:1565476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tuba1; RGD1565476
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in membrane raft. Orthologous to human TUBA1B (tubulin alpha 1b). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 4329.0), Brain (RPKM 4226.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tuba1b in Genome Data Viewer
    Location:
    7q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131969606..131972587, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130090663..130093644, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140614746..140617721, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene limb development membrane protein 1-like Neighboring gene ribosomal protein L13, pseudogene 3 Neighboring gene ribosomal protein L23a, pseudogene 8 Neighboring gene tubulin, alpha 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tubulin alpha-1B chain
    Names
    Alpha-tubulin 1
    Tubulin alpha-1 chain
    alpha-tubulin 2
    tubulin alpha-2 chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044270.3NP_001037735.1  tubulin alpha-1B chain

      See identical proteins and their annotated locations for NP_001037735.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q6P9V9
      UniProtKB/TrEMBL
      A0A8I6ALV8
      Related
      ENSRNOP00000075232.3, ENSRNOT00000083156.4
      Conserved Domains (1) summary
      PTZ00335
      Location:1440
      PTZ00335; tubulin alpha chain; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131969606..131972587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)