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    GPR146 G protein-coupled receptor 146 [ Homo sapiens (human) ]

    Gene ID: 115330, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR146provided by HGNC
    Official Full Name
    G protein-coupled receptor 146provided by HGNC
    Primary source
    HGNC:HGNC:21718
    See related
    Ensembl:ENSG00000164849 AllianceGenome:HGNC:21718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR8
    Summary
    Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in fat (RPKM 14.9), lung (RPKM 4.6) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR146 in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1044546..1059261)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1149540..1164255)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1084182..1098897)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cholesin Neighboring gene uncharacterized LOC124901570 Neighboring gene nonconserved acetylation island sequence 100 enhancer Neighboring gene hESC enhancers GRCh37_chr7:1067181-1067915 and GRCh37_chr7:1067916-1068649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1075522-1076044 Neighboring gene microRNA 339 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1076045-1076566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1080290-1080797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1081305-1081812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1083301-1083856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1091635-1092615 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:1095105-1095810 and GRCh37_chr7:1095811-1096516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25486 Neighboring gene Sharpr-MPRA regulatory region 11358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1109435-1110218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1110219-1111001 Neighboring gene CHLSN antisense RNA 1 Neighboring gene G protein-coupled estrogen receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor 146: new insights from genetics and model systems. Tharehalli U, et al. Curr Opin Lipidol, 2024 Jun 1. PMID 38465903
    2. Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile. Rimbert A, et al. Arterioscler Thromb Vasc Biol, 2022 Oct. PMID 36047410
    3. GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis. She L, et al. Acta Biochim Biophys Sin (Shanghai), 2020 Aug 5. PMID 32491159
    4. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice. Han F, et al. Cell Res, 2020 Apr. PMID 32203133, Free PMC Article
    5. Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes. Ryk A, et al. Cardiovasc Diabetol, 2024 Jun 20. PMID 38902687, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G protein-coupled receptor 146: new insights from genetics and model systems.
      Title: G protein-coupled receptor 146: new insights from genetics and model systems.
    2. GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
      Title: GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
    3. Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile.
      Title: Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile.
    4. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.
      Title: Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.
    5. GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis.
      Title: GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis.
    6. these findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism.
      Title: GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.
    7. Knockdown of GPR146 blocked C-peptide-induced cFos expression in KATOIII cells.
      Title: Evidence for an interaction between proinsulin C-peptide and GPR146.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cholesterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 146
    Names
    G-protein coupled receptor PGR8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303473.2 → NP_001290402.1  probable G-protein coupled receptor 146

      See identical proteins and their annotated locations for NP_001290402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC073957, AK300166, BC014241, BI910046, CD676083
      Consensus CDS
      CCDS5321.1
      UniProtKB/Swiss-Prot
      Q86SP5, Q96CH1
      UniProtKB/TrEMBL
      A4D2Q3
      Related
      ENSP00000410743.2, ENST00000444847.2
      Conserved Domains (1) summary
      cd14990
      Location:39 → 307
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001303474.2 → NP_001290403.1  probable G-protein coupled receptor 146

      See identical proteins and their annotated locations for NP_001290403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK300166, BC014241, DA169774
      Consensus CDS
      CCDS5321.1
      UniProtKB/Swiss-Prot
      Q86SP5, Q96CH1
      UniProtKB/TrEMBL
      A4D2Q3
      Conserved Domains (1) summary
      cd14990
      Location:39 → 307
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_138445.4 → NP_612454.1  probable G-protein coupled receptor 146

      See identical proteins and their annotated locations for NP_612454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK300166, AK313171, BC014241
      Consensus CDS
      CCDS5321.1
      UniProtKB/Swiss-Prot
      Q86SP5, Q96CH1
      UniProtKB/TrEMBL
      A4D2Q3
      Related
      ENSP00000380283.1, ENST00000397095.2
      Conserved Domains (1) summary
      cd14990
      Location:39 → 307
      7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      1044546..1059261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419864.1 → XP_047275820.1  probable G-protein coupled receptor 146 isoform X1

    2. XM_047419865.1 → XP_047275821.1  probable G-protein coupled receptor 146 isoform X1

    3. XM_011515116.4 → XP_011513418.1  probable G-protein coupled receptor 146 isoform X2

      See identical proteins and their annotated locations for XP_011513418.1

      Conserved Domains (1) summary
      pfam00001
      Location:63 → 314
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      1149540..1164255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357203.1 → XP_054213178.1  probable G-protein coupled receptor 146 isoform X1

    2. XM_054357204.1 → XP_054213179.1  probable G-protein coupled receptor 146 isoform X1

    3. XM_054357205.1 → XP_054213180.1  probable G-protein coupled receptor 146 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96CH1.1 GenPept UniProtKB/Swiss-Prot:Q96CH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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