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    puf-12 Pumilio domain-containing protein 12 [ Caenorhabditis elegans ]

    Gene ID: 174572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    puf-12
    Official Full Name
    Pumilio domain-containing protein 12
    Primary source
    WormBase:WBGene00014165
    Locus tag
    CELE_ZK945.3
    See related
    AllianceGenome:WB:WBGene00014165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of translation. Predicted to be active in nucleolus. Orthologous to human PUM3 (pumilio RNA binding family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See puf-12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (10100310..10103061)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative RING finger protein ZK945.4 Neighboring gene Ovule protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characteristics and evolution of the PUF gene family in Bombyx mori and 27 other species. Zhang CD, et al. Mol Biol Rep, 2012 Jan. PMID 21598114
    2. The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription. Akay A, et al. Dev Cell, 2017 Aug 7. PMID 28787591, Free PMC Article
    3. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
    4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pumilio domain-containing protein 12
    NP_496178.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10100310..10103061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063777.8 → NP_496178.1  Pumilio domain-containing protein 12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09622
      Conserved Domains (2) summary
      cl21719
      Location:292 → 553
      Pumilio; Pumilio-family RNA binding domain
      pfam08144
      Location:545 → 692
      CPL; CPL (NUC119) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09622.1

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