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    ilys-5 lysozyme [ Caenorhabditis elegans ]

    Gene ID: 180928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ilys-5
    Official Full Name
    lysozyme
    Primary source
    WormBase:WBGene00017691
    Locus tag
    CELE_F22A3.6
    See related
    AllianceGenome:WB:WBGene00017691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ilys-5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (6533490..6536840, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor ets-4 Neighboring gene Homeobox protein ceh-60 Neighboring gene Secreted protein Neighboring gene Tyrosine-protein kinase receptor svh-2 Neighboring gene Protein aaim-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional characterization of ILYS-5, a major invertebrate lysozyme of Caenorhabditis elegans. Berndt H, et al. Dev Comp Immunol, 2024 Oct. PMID 38925432
    2. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article
    3. TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals. Liudkovska V, et al. Sci Adv, 2022 Nov 18. PMID 36383655, Free PMC Article
    4. Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response. Mokoena NZ, et al. Med Microbiol Immunol, 2023 Oct. PMID 37672050, Free PMC Article
    5. Stable-isotope labeling with amino acids in nematodes. Larance M, et al. Nat Methods, 2011 Aug 28. PMID 21874007, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme
    NP_001024594.1
    • Confirmed by transcript evidence
    NP_001300339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6533490..6536840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029423.8 → NP_001024594.1  lysozyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19698
      Conserved Domains (1) summary
      pfam05497
      Location:17 → 135
      Destabilase; Destabilase

    2. NM_001313410.4 → NP_001300339.1  lysozyme [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYJ1
      Conserved Domains (1) summary
      pfam05497
      Location:3 → 110
      Destabilase; Destabilase

    RNA

    1. NR_132543.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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