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    usp-4 Ubiquitin carboxyl-terminal hydrolase [ Caenorhabditis elegans ]

    Gene ID: 177437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp-4
    Official Full Name
    Ubiquitin carboxyl-terminal hydrolase
    Primary source
    WormBase:WBGene00019259
    Locus tag
    CELE_H34C03.2
    See related
    AllianceGenome:WB:WBGene00019259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to several human genes including USP4 (ubiquitin specific peptidase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See usp-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (6757311..6762602)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Spindle defective protein 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. Basic M, et al. J Biol Chem, 2021 Nov. PMID 34600886, Free PMC Article
    2. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Dinkelmann MV, et al. Genetics, 2007 Nov. PMID 17947426, Free PMC Article
    3. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076
    4. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
    5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.
      Title: The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin carboxyl-terminal hydrolase
    NP_001293696.1
    • Confirmed by transcript evidence
    NP_501035.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6757311..6762602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068634.8 → NP_501035.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYY8
      Conserved Domains (3) summary
      smart00695
      Location:51 → 135
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:52 → 847
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:697 → 845
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    2. NM_001306767.3 → NP_001293696.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJY2
      Conserved Domains (2) summary
      smart00695
      Location:51 → 135
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:353 → 927
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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