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    gon-14 HAT C-terminal dimerization domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gon-14
    Official Full Name
    HAT C-terminal dimerization domain-containing protein
    Primary source
    WormBase:WBGene00002148
    Locus tag
    CELE_F44C4.4
    See related
    AllianceGenome:WB:WBGene00002148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including defecation; gonad morphogenesis; and negative regulation of vulval development. Located in nucleus. Is expressed in several structures, including amphid socket cell; anal sphincter muscle; gonad; pharyngeal segment; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gon-14 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (6606433..6611158, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene HoloCentric chromosome binding Protein Neighboring gene DUF4139 domain-containing protein;Protein F37C4.5;Transposase Neighboring gene Protein F37C4.5 Neighboring gene ncRNA Neighboring gene Cathepsin B-like cysteine proteinase 4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IRI-1, a LIN-15B homologue, interacts with inositol-1,4,5-triphosphate receptors and regulates gonadogenesis, defecation, and pharyngeal pumping in Caenorhabditis elegans. Walker DS, et al. Mol Biol Cell, 2004 Jul. PMID 15133127, Free PMC Article
    2. The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Siegfried KR, et al. Genetics, 2004 Jan. PMID 15020416, Free PMC Article
    3. gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Chesney MA, et al. Genetics, 2006 Feb. PMID 16322520, Free PMC Article
    4. Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts. Kroetz MB, et al. G3 (Bethesda), 2015 Oct 23. PMID 26497144, Free PMC Article
    5. Hermaphrodite cell-fate specification. Herman MA. WormBook, 2006 Jan 9. PMID 18050480, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IRI-1 functions in known itr-1-mediated processes: upregulation of pharyngeal pumping in response to food and control of the defecation cycle.
      Title: IRI-1, a LIN-15B homologue, interacts with inositol-1,4,5-triphosphate receptors and regulates gonadogenesis, defecation, and pharyngeal pumping in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defecation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HAT C-terminal dimerization domain-containing protein
    NP_741557.2
    • Confirmed by transcript evidence
    NP_741558.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6606433..6611158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171476.6 → NP_741558.2  HAT C-terminal dimerization domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741558.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4PIU4
      Conserved Domains (1) summary
      pfam05699
      Location:652 → 678
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    2. NM_171475.6 → NP_741557.2  HAT C-terminal dimerization domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741557.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L033
      Conserved Domains (1) summary
      pfam05699
      Location:652 → 678
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    Nucleotide Protein
    Heading Accession and Version

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