hid-1 Protein HID1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hid-1
Official Full Name: Protein HID1
Primary source: WormBase:WBGene00001844
Locus tag: CELE_K02E10.2
See related: AllianceGenome:WB:WBGene00001844
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including cellular response to carbon dioxide; defecation; and negative regulation of nematode pharyngeal pumping. Located in several cellular components, including Golgi cisterna; cytosol; and neuron projection. Is expressed in intestine; nervous system; pharynx; and uv1. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 105. Orthologous to human HID1 (HID1 domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hid-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (2489048..2494339)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing.
Title: The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.
HID-1 is a novel component of a DCV-based neurosecretory pathway and that it regulates one or more aspects of the biogenesis, maturation, or trafficking of DCVs.
Title: HID-1, a new component of the peptidergic signaling pathway.
HID-1 acts to prevent mis-sorting of peptide cargoes to lysosomes for degradation via a PtdIns3P-dependent trafficking pathway.
Title: HID-1 is a novel player in the regulation of neuropeptide sorting.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02E10.3 (e-PCR)
- UniSTS:315959

K02E10.2 (e-PCR)
- UniSTS:311366

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi medial cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi trans cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi trans cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein HID1

NP_001024748.1

Confirmed by transcript evidence

NP_001024749.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2489048..2494339

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029577.4 → NP_001024748.1 Protein HID1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024748.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EG65

Conserved Domains (1) summary

pfam12722
Location:1 → 726

Hid1; High-temperature-induced dauer-formation protein
NM_001029578.5 → NP_001024749.1 Protein HID1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024749.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7Z135

Conserved Domains (1) summary

pfam12722
Location:1 → 708

Hid1; High-temperature-induced dauer-formation protein