abce-1 ABC transporter, class E [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: abce-1
Official Full Name: ABC transporter, class E
Primary source: WormBase:WBGene00012714
Locus tag: CELE_Y39E4B.1
See related: AllianceGenome:WB:WBGene00012714
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity; iron ion binding activity; and ribosomal small subunit binding activity. Predicted to be involved in translational initiation and translational termination. Predicted to be active in cytosol. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to human ABCE1 (ATP binding cassette subfamily E member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See abce-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (13153817..13160284)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP-binding cassette protein E is involved in gene transcription and translation in Caenorhabditis elegans [ABCE]
Title: ATP-binding cassette protein E is involved in gene transcription and translation in Caenorhabditis elegans.
ABCE1 is able to suppress RNA silencing in Nicotiana benthamiana plants, in mammalian HEK293 cells and in the worm Caenorhabditis elegans.
Title: ABCE1 is a highly conserved RNA silencing suppressor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39E4B.1 (e-PCR)
- UniSTS:321723

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal small subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational termination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ABC transporter, class E

NP_499717.1

Product from WormBase gene class abce;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

13153817..13160284

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067316.8 → NP_499717.1 ABC transporter, class E [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499717.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2K8

Conserved Domains (5) summary

cd03236
Location:89 → 343

ABC_RNaseL_inhibitor_domain1; The ATP-binding cassette domain 1 of RNase L inhibitor

cd03237
Location:357 → 602

ABC_RNaseL_inhibitor_domain2; The ATP-binding cassette domain 2 of RNase L inhibitor

COG1245
Location:16 → 607

Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

pfam00037
Location:60 → 82

Fer4; 4Fe-4S binding domain

pfam04068
Location:17 → 47

RLI; Possible Fer4-like domain in RNase L inhibitor, RLI