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    pghm-1 putative peptidylglycine alpha-hydroxylating monooxygenase 1 [ Caenorhabditis elegans ]

    Gene ID: 171746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pghm-1
    Official Full Name
    putative peptidylglycine alpha-hydroxylating monooxygenase 1
    Primary source
    WormBase:WBGene00022144
    Locus tag
    CELE_Y71G12B.4
    See related
    AllianceGenome:WB:WBGene00022144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable copper ion binding activity and peptidylglycine monooxygenase activity. Predicted to be involved in peptide metabolic process. Predicted to be located in extracellular region and membrane. Is expressed in nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pghm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (1808092..1811835)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinases regulatory subunit Neighboring gene Apolipophorin Neighboring gene Uncharacterized protein Neighboring gene FBA_2 domain-containing protein Neighboring gene DUF38 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mass spectrometric evidence for neuropeptide-amidating enzymes in Caenorhabditis elegans. Van Bael S, et al. J Biol Chem, 2018 Apr 20. PMID 29487130, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidylglycine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative peptidylglycine alpha-hydroxylating monooxygenase 1
    NP_490898.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1808092..1811835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058497.8 → NP_490898.1  putative peptidylglycine alpha-hydroxylating monooxygenase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XM2
      Conserved Domains (2) summary
      pfam01082
      Location:27 → 145
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:167 → 313
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XM2.1

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