K05C4.5 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K05C4.5
Official Full Name: WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00010582
Locus tag: CELE_K05C4.5
See related: AllianceGenome:WB:WBGene00010582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome and t-UTP complex. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K05C4.5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (14742765..14747789)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K05C4.6 (e-PCR)
- UniSTS:312944

K05C4.5 (e-PCR)
- UniSTS:313227

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of t-UTP complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD_REPEATS_REGION domain-containing protein

NP_493567.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14742765..14747789

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061166.5 → NP_493567.2 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493567.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9XUU8

Conserved Domains (1) summary

COG2319
Location:59 → 297

WD40; WD40 repeat [General function prediction only]