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    mek-5 mitogen-activated protein kinase kinase [ Caenorhabditis elegans ]

    Gene ID: 172405, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mek-5
    Official Full Name
    mitogen-activated protein kinase kinase
    Primary source
    WormBase:WBGene00304811
    Locus tag
    CELE_E02D9.3
    See related
    AllianceGenome:WB:WBGene00304811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mek-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6802200..6804860)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing protein 174;DUF1754-domain-containing protein Neighboring gene K Homology domain-containing protein Neighboring gene Conserved secreted protein Neighboring gene ncRNA Neighboring gene Ubiquitin-like protease family profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Huang NN, et al. Development, 2002 Feb. PMID 11830574
    2. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase
    NP_740881.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6802200..6804860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170892.4 → NP_740881.1  mitogen-activated protein kinase kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TYV7
      Conserved Domains (1) summary
      smart00220
      Location:163 → 406
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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