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    chat-1 CDC50 family protein chat-1 [ Caenorhabditis elegans ]

    Gene ID: 177213, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chat-1
    Official Full Name
    CDC50 family protein chat-1
    Primary source
    WormBase:WBGene00019946
    Locus tag
    CELE_R08C7.2
    See related
    AllianceGenome:WB:WBGene00019946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including intestine. Orthologous to several human genes including TMEM30A (transmembrane protein 30A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chat-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (4447331..4449897)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene WAPL domain-containing protein;Wings apart-like protein homolog 1 Neighboring gene Histone H2A.V Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Flocculation protein FLO11-like Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1. Chen B, et al. PLoS Genet, 2010 Dec 9. PMID 21170358, Free PMC Article
    2. Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants. Li X, et al. Mol Biol Cell, 2013 Apr. PMID 23427264, Free PMC Article
    3. Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry. Beer KB, et al. Proc Natl Acad Sci U S A, 2018 Feb 6. PMID 29367422, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHAT-1 and TAT-1 maintain membrane phosphatidylserine asymmetry, thus promoting membrane tubulation and regulating endocytic sorting and recycling.
      Title: Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDC50 family protein chat-1
    NP_001023332.1
    • Confirmed by transcript evidence
    NP_001040979.1
    • Confirmed by transcript evidence
    NP_001368332.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4447331..4449897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028161.4 → NP_001023332.1  CDC50 family protein chat-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023332.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0H3, H2L0H4, Q2L6W0, U4PMW1
      Conserved Domains (1) summary
      pfam03381
      Location:72 → 333
      CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

    2. NM_001047514.4 → NP_001040979.1  CDC50 family protein chat-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0H3
      Conserved Domains (1) summary
      pfam03381
      Location:53 → 152
      CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

    3. NM_001380191.1 → NP_001368332.1  CDC50 family protein chat-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam03381
      Location:1 → 91
      CDC50; LEM3 (ligand-effect modulator 3) family / CDC50 family

    RNA

    1. NR_138505.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2L0H3.1

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