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    set-25 Histone-lysine N-methyltransferase set-25 [ Caenorhabditis elegans ]

    Gene ID: 3565129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-25
    Official Full Name
    Histone-lysine N-methyltransferase set-25
    Primary source
    WormBase:WBGene00012802
    Locus tag
    CELE_Y43F4B.3
    See related
    AllianceGenome:WB:WBGene00012802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K9 methyltransferase activity. Involved in negative regulation of gene expression, epigenetic. Located in heterochromatin. Is expressed in germ line; hypodermis; intestine; muscle cell; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-25 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (13283824..13293090, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene Syntaxin-1A homolog Neighboring gene NR LBD domain-containing protein Neighboring gene ncRNA Neighboring gene Nucleoporin SEH1 Neighboring gene PGM_PMM_I domain-containing protein;Phosphoglucomutase-2 Neighboring gene Kinesin-like protein klp-19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-cell dynamics of chromatin activity during cell lineage differentiation in Caenorhabditis elegans embryos. Zhao Z, et al. Mol Syst Biol, 2021 Apr. PMID 33900055, Free PMC Article
    2. Transgenerational transmission of environmental information in C. elegans. Klosin A, et al. Science, 2017 Apr 21. PMID 28428426
    3. Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. Woodhouse RM, et al. Cell Rep, 2018 Nov 20. PMID 30463020
    4. Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability. Zeller P, et al. Nat Genet, 2016 Nov. PMID 27668659
    5. piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans. Ashe A, et al. Cell, 2012 Jul 6. PMID 22738725, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the putative histone methyltransferases SET-25 and SET-32 are required for establishment of a transgenerational silencing signal but not for long-term maintenance of this signal between subsequent generations
      Title: Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.
    2. Study shows that MET-2, a SETDB1 homolog, deposits mono- and dimethyl groups at H3K9, whereas SET-25, a previously uncharacterized histone methyltransferases, trimethylates the same residue. SET-25 colocalizes with peripheral heterochromatin in an H3K9me3-dependent fashion, thus becoming sequestered at the nuclear periphery by the product of its own methylation reaction.
      Title: Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K9 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear lamina IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone-lysine N-methyltransferase set-25
    NP_499738.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13283824..13293090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067337.6 → NP_499738.3  Histone-lysine N-methyltransferase set-25 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499738.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEU2
      Conserved Domains (1) summary
      pfam00856
      Location:559 → 686
      SET; SET domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEU2.1

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