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    hrg-10 DUF833-domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrg-10
    Official Full Name
    DUF833-domain-containing protein
    Primary source
    WormBase:WBGene00013587
    Locus tag
    CELE_Y80D3A.9
    See related
    AllianceGenome:WB:WBGene00013587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in Golgi organization and protein secretion. Predicted to be active in Golgi apparatus. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in TANGO2-related metabolic encephalopathy and arrythmias. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrg-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (18953118..18957317, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Protein-tyrosine-phosphatase Neighboring gene C2H2-type domain-containing protein Neighboring gene DUF4124 domain-containing protein;Ricin B-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Sun F, et al. Nature, 2022 Oct. PMID 36261532, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DUF833-domain-containing protein
    NP_507692.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18953118..18957317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075291.2 → NP_507692.1  DUF833-domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1Q8
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 260
      TANGO2; Transport and Golgi organization 2
    Nucleotide Protein
    Heading Accession and Version

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