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    F44E7.9 Rab5-interacting protein [ Caenorhabditis elegans ]

    Gene ID: 185741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F44E7.9
    Official Full Name
    Rab5-interacting protein
    Primary source
    WormBase:WBGene00018431
    Locus tag
    CELE_F44E7.9
    See related
    AllianceGenome:WB:WBGene00018431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial respirasome assembly. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 2. Orthologous to human RAB5IF (RAB5 interacting factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F44E7.9 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (5791230..5792229)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene N-acetylgalactosaminide beta-1,3-galactosyltransferase Neighboring gene UDP-galactose transporter Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab5-interacting protein
    NP_504519.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5791230..5792229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072118.5 → NP_504519.1  Rab5-interacting protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16254
      Conserved Domains (1) summary
      pfam07019
      Location:36 → 112
      Rab5ip; Rab5-interacting protein (Rab5ip)
    Nucleotide Protein
    Heading Accession and Version

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