hlh-13 Helix-loop-helix protein 13 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hlh-13
Official Full Name: Helix-loop-helix protein 13
Primary source: WormBase:WBGene00001957
Locus tag: CELE_F48D6.3
See related: AllianceGenome:WB:WBGene00001957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor binding activity. Involved in dauer exit and response to oxidative stress. Predicted to be located in nucleus. Is expressed in neurons. Orthologous to human FERD3L (Fer3 like bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hlh-13 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (4249249..4250766)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hlh-13, the worm homolog of p48, is also expressed in DA neurons. Unlike the fly counterpart, hlh-13 loss-of-function does not impair development or survival of DA neurons under normal growth conditions
Title: A conserved role for p48 homologs in protecting dopaminergic neurons from oxidative stress.
identified HLH-13 as a novel DAF-16 target gene and linked its function to known outputs of Insulin/IGF-signaling
Title: Combined informatic and expression screen identifies the novel DAF-16 target HLH-13.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F48D6.3 (e-PCR)
- UniSTS:319370

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dauer exit	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Helix-loop-helix protein 13

NP_508725.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4249249..4250766

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076324.5 → NP_508725.1 Helix-loop-helix protein 13 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508725.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20561

Conserved Domains (1) summary

pfam00010
Location:43 → 93

HLH; Helix-loop-helix DNA-binding domain