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    him-1 Structural maintenance of chromosomes protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    him-1
    Official Full Name
    Structural maintenance of chromosomes protein 1
    Primary source
    WormBase:WBGene00001860
    Locus tag
    CELE_F28B3.7
    See related
    AllianceGenome:WB:WBGene00001860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA binding activity. Involved in several processes, including chromosome segregation; response to UV; and response to X-ray. Located in chromatin and nucleus. Part of cohesin complex. Is expressed in germ line; linker cell; and somatic cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 2; congestive heart failure; and developmental and epileptic encephalopathy 85. Orthologous to several human genes including SMC1B (structural maintenance of chromosomes 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See him-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (4951571..4957667, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein Neighboring gene Chloride channel protein CLC-d Neighboring gene Uncharacterized protein Neighboring gene Mitotic spindle organiZing protein (MOZART) homolog Neighboring gene ENhancer of Uncoordination

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sperm isolation and biochemical analysis of the major sperm protein from Caenorhabditis elegans. Klass MR, et al. Dev Biol, 1981 Jun. PMID 20737868
    2. Centriole engagement: it's not just cohesin any more. Sluder G. Curr Biol, 2013 Aug 5. PMID 23928085
    3. The role of chromosome ends during meiosis in Caenorhabditis elegans. Wicky C, et al. Bioessays, 1996 Jun. PMID 8787533
    4. Chromosome rearrangements in Caenorhabditis elegans. Herman RK, et al. Genetics, 1976 May. PMID 1269921, Free PMC Article
    5. cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis. Stanvitch G, et al. Genetics, 2008 Jan. PMID 18202360, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Structural maintenance of chromosomes protein 1
    NP_001040658.2
    • Confirmed by transcript evidence
    NP_001040659.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4951571..4957667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047193.6 → NP_001040658.2  Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040658.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01789, Q2A957
      Conserved Domains (1) summary
      pfam02463
      Location:15 → 1232
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_001047194.3 → NP_001040659.1  Structural maintenance of chromosomes protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01789
      Conserved Domains (2) summary
      cd03275
      Location:15 → 118
      ABC_SMC1_euk; ATP-binding cassette domain of eukaryotic SMC1 proteins
      pfam02463
      Location:1 → 110
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01789.4

    Gene LinkOut

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