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    mlp-1 LIM zinc-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175847, updated on 9-Dec-2024

    Summary

    Official Symbol
    mlp-1
    Official Full Name
    LIM zinc-binding domain-containing protein
    Primary source
    WormBase:WBGene00003375
    Locus tag
    CELE_T04C9.4
    See related
    AllianceGenome:WB:WBGene00003375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Located in striated muscle dense body. Is expressed in several structures, including intestine; nervous system; non-striated muscle; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to several human genes including CSRP1 (cysteine and glycine rich protein 1); CSRP2 (cysteine and glycine rich protein 2); and CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mlp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5971527..5973665, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein dct-6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FERM domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding  

    General protein information

    Preferred Names
    LIM zinc-binding domain-containing protein
    NP_001263705.1
    • Confirmed by transcript evidence
    NP_001360006.1
    • Confirmed by transcript evidence
    NP_001367782.1
    • Confirmed by transcript evidence
    NP_498300.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5971527..5973665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276776.3NP_001263705.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E6X8
      Conserved Domains (1) summary
      cd09404
      Location:1063
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    2. NM_001372606.4NP_001360006.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GP94
      Conserved Domains (1) summary
      cd09404
      Location:1063
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    3. NM_065899.8NP_498300.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498300.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZV8
      Conserved Domains (1) summary
      cd09404
      Location:1063
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    4. NM_001379735.3NP_001367782.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GP96
      Conserved Domains (1) summary
      cd09404
      Location:1063
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
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