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    bath-44 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bath-44
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00015567
    Locus tag
    CELE_C07D10.2
    See related
    AllianceGenome:WB:WBGene00015567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Is expressed in pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bath-44 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (7394955..7397351)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene PAP-associated domain-containing protein Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene F-box domain-containing protein Neighboring gene Zinc metalloproteinase nas-7 Neighboring gene Serpentine receptor class delta-55 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. An SWA, et al. Aging Cell, 2019 Jun. PMID 30773781, Free PMC Article
    2. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Fridolfsson HN, et al. Dev Biol, 2010 Feb 15. PMID 20005871, Free PMC Article
    3. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
    4. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_495549.1
    • Confirmed by transcript evidence
    NP_495550.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7394955..7397351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063149.5 → NP_495550.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17782
      Conserved Domains (4) summary
      smart00225
      Location:204 → 300
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00121
      Location:26 → 167
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cd14734
      Location:300 → 362
      SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:193 → 296
      BTB; BTB/POZ domain

    2. NM_063148.7 → NP_495549.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYJ3
      Conserved Domains (4) summary
      smart00225
      Location:211 → 307
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00121
      Location:26 → 174
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cd14734
      Location:307 → 369
      SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:200 → 303
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version

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