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    snr-6 putative small nuclear ribonucleoprotein E [ Caenorhabditis elegans ]

    Gene ID: 176668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snr-6
    Official Full Name
    putative small nuclear ribonucleoprotein E
    Primary source
    WormBase:WBGene00004919
    Locus tag
    CELE_Y49E10.15
    See related
    AllianceGenome:WB:WBGene00004919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Is expressed in gonad. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; hypotrichosis 1; hypotrichosis 11; and lupus nephritis. Orthologous to human SNRPE (small nuclear ribonucleoprotein polypeptide E). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snr-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (12429172..12429629, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Proteoglycan 4 Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene Phospholipid-transporting ATPase tat-1 Neighboring gene Pharynx and intestine in excess protein 1 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene TAZ-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesis. Barbee SA, et al. Curr Biol, 2002 Sep 3. PMID 12225665
    2. The Sm proteins regulate germ cell specification during early C. elegans embryogenesis. Barbee SA, et al. Dev Biol, 2006 Mar 1. PMID 16413530
    3. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article
    4. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article
    5. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative small nuclear ribonucleoprotein E
    NP_499620.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12429172..12429629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067219.4 → NP_499620.1  putative small nuclear ribonucleoprotein E [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTU6
      Conserved Domains (1) summary
      cd01718
      Location:8 → 85
      Sm_E; Sm protein E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTU6.1

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