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    Y116A8C.27 ATP synthase mitochondrial F1 complex assembly factor 2;DUF3800 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y116A8C.27
    Official Full Name
    ATP synthase mitochondrial F1 complex assembly factor 2;DUF3800 domain-containing protein
    Primary source
    WormBase:WBGene00013804
    Locus tag
    CELE_Y116A8C.27
    See related
    AllianceGenome:WB:WBGene00013804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y116A8C.27 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (17090640..17096268, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PX domain-containing protein;PXA domain-containing protein;Sorting nexin-13 Neighboring gene Lipoprotein;Recep_L_domain domain-containing protein Neighboring gene Small nuclear ribonucleoprotein Sm D3 Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Carbonic anhydrase Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton-transporting ATP synthase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase mitochondrial F1 complex assembly factor 2;DUF3800 domain-containing protein
    NP_001255920.1
    • Confirmed by transcript evidence
    NP_001255921.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17090640..17096268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268991.5 → NP_001255920.1  ATP synthase mitochondrial F1 complex assembly factor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2U3
      Conserved Domains (1) summary
      pfam07542
      Location:25 → 150
      ATP12; ATP12 chaperone protein

    2. NM_001268992.3 → NP_001255921.1  DUF3800 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQA8
      Conserved Domains (1) summary
      cl02228
      Location:1 → 167
      ATP12; ATP12 chaperone protein
    Nucleotide Protein
    Heading Accession and Version

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