apc-2 Anaphase-promoting complex subunit 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: apc-2
Official Full Name: Anaphase-promoting complex subunit 2
Primary source: WormBase:WBGene00000143
Locus tag: CELE_K06H7.6
See related: AllianceGenome:WB:WBGene00000143
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in metaphase/anaphase transition of mitotic cell cycle and protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC2 (anaphase promoting complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See apc-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 15

Sequence:: Chromosome: III; NC_003281.10 (8080629..8083701)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that accumulation of dynein at poles was kinesin-1 independent and APC dependent, just like dynein driven spindle movements.
Title: Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K06H7.5 (e-PCR)
- UniSTS:311441

K06H7.6 (e-PCR)
- UniSTS:311442

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Anaphase-promoting complex subunit 2

NP_498762.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8080629..8083701

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066361.7 → NP_498762.2 Anaphase-promoting complex subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498762.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34513, P34514

Conserved Domains (2) summary

smart01013
Location:662 → 723

APC2; Anaphase promoting complex (APC) subunit 2

smart00182
Location:408 → 553

CULLIN; Cullin