nab-1 NeurABin;Neurabin-1;Neurabin-2 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: nab-1
Official Full Name: NeurABin;Neurabin-1;Neurabin-2
Primary source: WormBase:WBGene00003516
Locus tag: CELE_C43E11.6
See related: AllianceGenome:WB:WBGene00003516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in synapse assembly. Located in actin cytoskeleton; presynaptic active zone; and presynaptic periactive zone. Is expressed in several structures, including egg-laying apparatus; excretory canal; hermaphrodite distal tip cell; neurons; and somatic nervous system. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A) and PPP1R9B (protein phosphatase 1 regulatory subunit 9B). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See nab-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (4229570..4236115)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIC-1 affects Wnt secretion by modulating the actin cytoskeleton through its interaction with the actin-binding protein NAB-1.
Title: Wnt Secretion Is Regulated by the Tetraspan Protein HIC-1 through Its Interaction with Neurabin/NAB-1.
A single glycine residue in a conserved domain of the C. elegans CED-10 is crucial for controlling neurite outgrowth in a partially non-redundant manner. When CED-10 function is diminished, the adaptor protein NAB-1 and its interacting partner SYD-1 can act as inhibitors of axon outgrowth.
Title: Distinct CED-10/Rac1 domains confer context-specific functions in development.
The data of this study suggested that NAB-1 serves as an adaptor protein that links synaptogenic signals from transmembrane adhesion molecules to intracellular recruitment of active zones to specific subcellular domains.
Title: NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.
Neurabin functions as a scaffold to facilitate SAD-1-mediated phosphorylation for substrates specific for restricting axonal fate during neuronal polarization.
Title: Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C43E11.6 (e-PCR)
- UniSTS:308761

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: NeurABin;Neurabin-1;Neurabin-2

NP_001367535.1

Confirmed by transcript evidence

NP_001367538.1

Confirmed by transcript evidence

NP_001370468.1

Confirmed by transcript evidence

NP_001370469.1

Product from WormBase gene class nab;
Confirmed by transcript evidence

NP_001379700.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4229570..4236115

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382888.1 → NP_001370468.1 Neurabin-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95Q64

Conserved Domains (4) summary

cd09512
Location:469 → 528

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:100 → 188

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12704
Location:247 → 373

PRK12704; phosphodiesterase; Provisional

pfam17817
Location:63 → 94

PDZ_5; PDZ domain
NM_001379751.3 → NP_001367535.1 Neurabin-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KYW1

Conserved Domains (4) summary

cd09512
Location:629 → 688

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:260 → 348

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12704
Location:407 → 533

PRK12704; phosphodiesterase; Provisional

pfam17817
Location:200 → 254

PDZ_5; PDZ domain
NM_001379754.3 → NP_001367538.1 Neurabin-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KYW3

Conserved Domains (4) summary

cd09512
Location:566 → 625

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:197 → 285

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12704
Location:344 → 470

PRK12704; phosphodiesterase; Provisional

pfam17817
Location:137 → 191

PDZ_5; PDZ domain
NM_001382891.1 → NP_001370469.1 NeurABin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KYW2
NM_001392124.1 → NP_001379700.1 Neurabin-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q5R3Y6

Conserved Domains (4) summary

cd09512
Location:435 → 494

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:66 → 154

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK12704
Location:213 → 339

PRK12704; phosphodiesterase; Provisional

pfam17817
Location:6 → 60

PDZ_5; PDZ domain