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    unc-122 Olfactomedin-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-122
    Official Full Name
    Olfactomedin-like domain-containing protein
    Primary source
    WormBase:WBGene00006845
    Locus tag
    CELE_F11C3.2
    See related
    AllianceGenome:WB:WBGene00006845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of cholinergic synaptic transmission. Located in postsynaptic membrane. Is expressed in body wall musculature; coelomocyte; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to several human genes including GLDN (gliomedin) and OLFML2B (olfactomedin like 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-122 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (14872112..14875436)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Myosin-4 Neighboring gene ATP-dependent DNA helicase Neighboring gene FERM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane Collagens in Neuromuscular Development and Disorders. Wakabayashi T. Front Mol Neurosci, 2020. PMID 33536873, Free PMC Article
    2. DVC interneuron cGAL driver in Caenorhabditis elegans. Oh JY, et al. MicroPubl Biol, 2019 Mar 6. PMID 32550476, Free PMC Article
    3. Genetic mosaics. Yochem J, et al. WormBook, 2005 Dec 27. PMID 18023118, Free PMC Article
    4. A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans. Loria PM, et al. J Neurosci, 2004 Mar 3. PMID 14999070, Free PMC Article
    5. Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans. Gat A, et al. Cell Rep, 2023 Sep 26. PMID 37691148

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of synaptic transmission, cholinergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Olfactomedin-like domain-containing protein
    NP_001309456.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14872112..14875436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322696.3 → NP_001309456.1  Olfactomedin-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGP1, Q6RSA2
      Conserved Domains (2) summary
      pfam01391
      Location:112 → 161
      Collagen; Collagen triple helix repeat (20 copies)
      pfam02191
      Location:294 → 556
      OLF; Olfactomedin-like domain
    Nucleotide Protein
    Heading Accession and Version

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