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    lin-25 Protein lin-25 [ Caenorhabditis elegans ]

    Gene ID: 179732, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-25
    Official Full Name
    Protein lin-25
    Primary source
    WormBase:WBGene00003011
    Locus tag
    CELE_F56H9.5
    See related
    AllianceGenome:WB:WBGene00003011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-positive bacterium and vulval development. Acts upstream of or within with a positive effect on cell fate specification. Located in cytoplasm and nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; hermaphrodite distal tip cell; and vulval cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lin-25 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (12649925..12658714)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein alpha-8 subunit Neighboring gene ShKT domain-containing protein Neighboring gene Guanine nucleotide-binding protein alpha-9 subunit Neighboring gene M247R Neighboring gene C3H1-type domain-containing protein Neighboring gene Histone H3.3-like type 2 Neighboring gene Saposin B-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signal transduction during C. elegans vulval induction. Sternberg PW, et al. Trends Genet, 1991 Nov-Dec. PMID 1668188
    2. lin-25, a gene required for vulval induction in Caenorhabditis elegans. Tuck S, et al. Genes Dev, 1995 Feb 1. PMID 7867931
    3. A perfect vulva every time: gradients and signaling cascades in C. elegans. Kenyon C. Cell, 1995 Jul 28. PMID 7628006
    4. Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving Ras and the identification and characterization of evolutionarily conserved domains. Nilsson L, et al. Genetics, 2000 Nov. PMID 11063686, Free PMC Article
    5. The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo. Natarajan L, et al. Genetics, 2001 Sep. PMID 11560894, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lin-25
    NP_506162.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12649925..12658714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073761.8 → NP_506162.1  Protein lin-25 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10573, Q7JLH0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10573.1

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