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    ptr-9 Patched-related protein 9 [ Caenorhabditis elegans ]

    Gene ID: 191747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptr-9
    Official Full Name
    Patched-related protein 9
    Primary source
    WormBase:WBGene00004223
    Locus tag
    CELE_F54G8.5
    See related
    AllianceGenome:WB:WBGene00004223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in molting cycle. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human PTCHD1 (patched domain containing 1); PTCHD3 (patched domain containing 3 (gene/pseudogene)); and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptr-9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (9157204..9161653, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene RING finger protein nhl-1;RING-type domain-containing protein Neighboring gene Protein irld-34 Neighboring gene ncRNA Neighboring gene putative diacylglycerol kinase 3 Neighboring gene Integrin alpha ina-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Patched-related protein 9
    NP_499030.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9157204..9161653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066629.6 → NP_499030.2  Patched-related protein 9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499030.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03602
      Conserved Domains (2) summary
      pfam02460
      Location:52 → 817
      Patched; Patched family
      pfam12349
      Location:288 → 439
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03602.2

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