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    nphp-1 Nephrocystin-1-like protein [ Caenorhabditis elegans ]

    Gene ID: 174643, updated on 9-Dec-2024

    Summary

    Official Symbol
    nphp-1
    Official Full Name
    Nephrocystin-1-like protein
    Primary source
    WormBase:WBGene00010898
    Locus tag
    CELE_M28.7
    See related
    AllianceGenome:WB:WBGene00010898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including determination of adult lifespan; male mating behavior; and non-motile cilium assembly. Located in several cellular components, including ciliary basal body; ciliary base; and ciliary transition zone. Is expressed in nervous system and postcloacal sensillum. Used to study nephronophthisis. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Joubert syndrome 4; Senior-Loken syndrome; nephronophthisis; and nephronophthisis 1. Orthologous to human NPHP1 (nephrocystin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See nphp-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (10648893..10652256, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Protein tweety homolog Neighboring gene ncRNA Neighboring gene Flo11 domain-containing protein Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene Small nuclear ribonucleoprotein associated homolog 13

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuronal signal transduction IC
    Inferred by Curator
    more info
    PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein localization involved in establishment of planar polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hermaphrodite contact IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in turning behavior involved in mating IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Nephrocystin-1-like protein
    NP_496298.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10648893..10652256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063897.5NP_496298.1  Nephrocystin-1-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496298.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17972, Q21570
      Conserved Domains (1) summary
      cl17036
      Location:220271
      SH3; Src Homology 3 domain superfamily