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    nhr-237 NR LBD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-237
    Official Full Name
    NR LBD domain-containing protein
    Primary source
    WormBase:WBGene00021610
    Locus tag
    CELE_Y46H3D.6
    See related
    AllianceGenome:WB:WBGene00021610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in anal region; nervous system; and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-237 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (1625189..1626820, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene NR LBD domain-containing protein;Nuclear receptor domain-containing protein Neighboring gene Nuclear receptor Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257
    2. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NR LBD domain-containing protein
    NP_001300258.1
    • Partially confirmed by transcript evidence
    NP_503460.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1625189..1626820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313329.4 → NP_001300258.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AW28
      Conserved Domains (2) summary
      smart00399
      Location:13 → 64
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      pfam00104
      Location:103 → 295
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor

    2. NM_071059.3 → NP_503460.1  NR LBD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q966B8
      Conserved Domains (2) summary
      smart00399
      Location:9 → 80
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
      pfam00104
      Location:119 → 311
      Hormone_recep; Ligand-binding domain of nuclear hormone receptor
    Nucleotide Protein
    Heading Accession and Version

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